定义
美国FDA 物质登记 · UNII 1O6WQ6T7G3 · 登记名称 Tafluprost · 单一化学物质
Tafluprost is a prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It has a role as a prostaglandin receptor agonist. It is an isopropyl ester, a prostaglandins Falpha and an organofluorine compound. It is functionally related to a prostaglandin F2alpha.
来源: PubChem
化妆品中的作用
安全与法规参考
- 禁用
- 加拿大
来源: 韩国食药处 化妆品法规信息
加拿大化妆品成分热点清单 · 禁止用于化妆品
来源: 加拿大禁用·限用成分清单
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 209860-87-7
- DTXSID美国EPA化学品编号
- DTXSID401021504
- DTXCID美国EPA化合物编号
- DTXCID601506522
- IUPAC
- Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate
- 分子式
- C25H34F2O5
- 分子量
- 452.539 g/mol
实测物性
- 性状
- Liquid
- 沸点
- 100°C
- 熔点
- 87.5 °C
- 溶解性
- Insoluble · 5.28e-03 g/L
- 解离常数
- 5.5-6.7
这是对物质本身测得的数值，并非原料商品的规格。
来源: PubChem
产品实际使用的用途
相关文献
- Effects of Tafluprost on Ocular Blood Flow · 2022
- Effects of 0.0015% preservative-free tafluprost on the equine eye. · 2021
- Efficacy of preserved Tafluprost 0.0015% in lowering intraocular pressure · 2023
- Assessment of the optic nerve head, peripapillary, and macular microcirculation in the newly diagnosed patients with primary open-angle glaucoma treated with topical tafluprost and tafluprost/timolol fixed combination · 2019
- Efficacy and Safety of Switching from Tafluprost to a Tafluprost/Timolol Fixed Combination in Patients With Primary Open-Angle Glaucoma · 2018