What is this ingredient?

미국 FDA 물질 등록 · UNII 42064KRE49 · 등록명 TETRAETHYL SILICATE · 단일 화학물질

All ingredients

Ingredient Dictionary

TETRAETHYL ORTHOSILICATE

Definition

US FDA substance register · UNII 42064KRE49 · registered name TETRAETHYL SILICATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Tetraethyl Orthosilicate is the organic compound that conforms to the formula:

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

TETRAETHYL ORTHOSILICATEINCISilicic acid (H4SiO4), tetraethyl esterSynonym

CAS No.chemical registry number: 78-10-4
EC No.EU chemical inventory number: 201-083-8
DTXSIDUS EPA chemical ID: DTXSID6026450
DTXCIDUS EPA compound ID: DTXCID906450

IUPAC: Tetraethyl silicate
Molecular formula: C8H20O4Si
Molecular weight: 208.329 g/mol

Measured properties

Appearance: Ethyl silicate appears as a clear colorless liquid with a faint odor. Flash point 125 °F. Less dense than water. Vapors are heavier than air. · Other Solid, CBI, Liquid
Odour: SHARP, ESTER-LIKE ODOR · Faint odor
Boiling point: 336 °F at 760 mmHg (USCG, 1999) · 168.8 °C
Melting point: -121.9 °F (USCG, 1999) · -82.5 °C
Solubility: Reacts with water (NIOSH, 2024) · Soluble in ether
Density: 0.933 at 68 °F (USCG, 1999) - Less dense than water, will float · 0.933 at 20 °C
Viscosity: 0.6 cP at 25 °C · 0.6 cP(25 deg C)
Colour: colourless
Melting/freezing point: -82.5 ℃
Initial boiling point and range: 168.8 ℃
Flash point: 45 ℃
Upper/lower flammability or explosive limits: 23 / 1.3 %
Vapour pressure: 1.88 ㎜Hg(25 deg C)
Water solubility: 1.49 g/ℓ(23 ℃)
Vapour density: 7.22
Relative density: 0.933 (20 deg C)
n-Octanol/water partition coefficient (Kow): 0.04
Auto-ignition temperature: 222 ℃(96.08 to 96.28 kPa)
Molecular weight: 208.3

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 17 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Chemical reaction regulator4
Hardener2
Binder2
Intermediate2
Filler2
Film former1
Monomers1
No specific technical function1

2 other uses

Viscosity modifier1
Impregnation agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 4 eye studies are on record.

Classed as moderate1Classed as low2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Classification not possible
Skin Sensitization · Screening
Category 6.3B (Category 3)
Skin Irritation · Read Across
Category 2
Skin Irritation · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Eye Irrit. 2
Eye Irritation · Authoritative
Category 2
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across