Tetramethylpyrazine is a member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups.
Definition
Tetramethylpyrazine is a member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii). It has a role as an antineoplastic agent, a vasodilator agent, a platelet aggregation inhibitor, a neuroprotective agent, an apoptosis inhibitor and a bacterial metabolite. It is an alkaloid and a member of pyrazines.
Source: PubChem
US FDA substance register · UNII V80F4IA5XG · registered name LIGUSTRAZINE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1124-11-4
- EC No.EU chemical inventory number
- 214-391-2
- DTXSIDUS EPA chemical ID
- DTXSID6047070
- DTXCIDUS EPA compound ID
- DTXCID4027070
- IUPAC
- Tetramethylpyrazine
- Molecular formula
- C8H12N2
- Molecular weight
- 136.198 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 84~86 ℃
- Initial boiling point and range
- 190 ℃
- Vapour pressure
- 0.169 ㎜Hg (@ 25 ℃, est.)
- Water solubility
- 7010 ㎎/ℓ (@ 25 ℃, est.)
- Vapour density
- 4.7
- n-Octanol/water partition coefficient (Kow)
- 1.28
- Molecular weight
- 136.20
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient2
- Fragrance2
Source: US EPA CompTox dashboard
Related literature
- Tetramethylpyrazine-loaded liposomes surrounded by hydrogel based on sodium alginate and chitosan as a multifunctional drug delivery System for treatment of atopic dermatitis. · 2023
- [Preparation and in vitro permeation of tetramethylpyrazine hydrochloride transdermal gel]. · 2013
- Single- and multiple-dose pharmacokinetics of a novel tetramethylpyrazine reservoir-type transdermal patch versus tetramethylpyrazine phosphate oral tablets in healthy normal volunteers, and in vitro/in vivo correlation. · 2013
- Study on the inhibitory effects of tetramethylpyrazine on proliferation of bovine lens epithelial cells · 2013
- [Perioperative intervention of tetramethylpyrazine on free skin flap transplantation]. · 2010
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese