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Ingredients

Ingredient Dictionary

TETRASODIUM ETIDRONATE

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 4 list it before the 1% line and 17 after it (usually 1% or less).

Products using this ingredient

12 of 21 confirmed · likeliest to carry enough first · See all 21

Definition

US FDA substance register · UNII CZZ9T1T1X4 · registered name ETIDRONATE TETRASODIUM · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Adjusts thicknessVISCOSITY CONTROLLINGKeeps an emulsion from separatingEMULSION STABILISINGBinds metal ions to prevent spoilageCHELATING

Safety & regulatory references

Restricted
China · South Korea

Source: MFDS (Korea) cosmetic regulatory information

Argentina · Brazil

  • Field of application and/or use : (a) Products for hair care (b) Soaps
  • Maximum concentration permitted at final product : a.- 1.5% (calculated as Etidronic Acid) b.- 0.2% (calculated as Etidronic Acid)

ASEAN

  • Field of application and/or use : (a) Hair-care (b) Soap
  • Maximum authorised concentration in the finished cosmetic product : (a) 1.5% expressed as etidronic acid (b) 0.2% expressed as etidronic acid

European Union

  • Product Type, body parts : (a) Hair product (b) Soap
  • Maximum concentration in ready for use preparation : (a) 1.5% (as etidronic acid) (b) 0.2% (as etidronic acid)

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction III/53

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report: Safety Assessment of Etidronic Acid and Its Salts as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name エチドロン酸4Na: 本品は、エチドロン酸(*)の四ナトリウム塩であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

TETRASODIUM ETIDRONATEINCI테트라소듐에티드로네이트Korean label name (MFDS standard)Phosphonic acid, (1-hydroxyethylidene)bis-, tetrasodium saltSynonymエチドロン酸4NaJapanese labelling name
CAS No.chemical registry number
3794-83-0
EC No.EU chemical inventory number
223-267-7
DTXSIDUS EPA chemical ID
DTXSID7029663
DTXCIDUS EPA compound ID
DTXCID109663
IUPAC
Tetrasodium (1-hydroxyethane-1,1-diyl)bis(phosphonate)
Molecular formula
C2H4Na4O7P2
Molecular weight
293.954 g/mol

Measured properties

Appearance
solid
n-Octanol/water partition coefficient (Kow)
12.28
Molecular weight
293.96

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 73 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Chelating agent65
  • Viscosity modifier2
  • Anti-scaling agent2
  • Emulsifier2
  • Cleaning agent1
  • Flow promoter1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 3 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Eye irritation - category 2A
    Eye Irritation · Screening
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
  • Severe Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to

Source: US EPA CompTox dashboard

Related literature

Linked databases 17