Thiabendazole is a member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2.
定義
Thiabendazole is a member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. It has a role as an antinematodal drug and an antifungal agrochemical. It is a member of benzimidazoles, a member of 1,3-thiazoles and a benzimidazole fungicide. It derives from a hydride of a 1H-benzimidazole.
出典: PubChem
米国FDA 物質登録 · UNII N1Q45E87DT · 登録名 Thiabendazole · 単一の化学物質
化粧品での役割
安全性・規制情報
- 禁止
- ASEAN
出典: ASEAN 化粧品指令
韓国の有害物質GHS分類なし · 既存化学物質
Other restriction: ban substances that deplete the ozone layer
出典: EU CosIng 成分リスト
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
- CAS No.化学物質登録番号
- 148-79-8
- EC No.EU化学物質目録番号
- 205-725-8
- DTXSID米国EPA化学物質番号
- DTXSID0021337
- DTXCID米国EPA化合物番号
- DTXCID401337
- IUPAC
- 2-(1,3-Thiazol-4-yl)-1H-1,3-benzimidazole
- 分子式
- C10H7N3S
- 分子量
- 201.25 g/mol
測定された物性
- 性状
- Thiabendazole appears as white or cream-colored odorless, tasteless powder. Sublimes above 590 °F. Fluoresces in acidic solution. Formulated as a dust, flowable powder or wettable powder for use as a systemic fungicide and anthelmintic. · Colorless, white, or tan odorless solid, [HSDB] Colorless solid, [EPA REDs] Off-white to yellow-tan solid, [CPSQ]
- 臭い
- Odorless · 無臭
- 融点
- 579 to 581 °F (NTP, 1992) · 300 °C
- 溶解性
- less than 1 mg/mL at 70 °F (NTP, 1992) · 50 mg/L (at 25 °C)
- 密度
- Amber liquid, density: 1.103 at 25 °C /Thiabendazole hypophosphite/
- 安定性
- Non-volatile at room temp, stable in water and in acid and alkaline soln, stable under normal conditions to hydrolysis, light, and heat.
- 解離定数
- 4.64 (at 25 °C) · pKa = 4.64
- 融点・凝固点
- 304~305 ℃
- 溶解度
- 50 ㎎/ℓ (25℃)
- n-オクタノール/水分配係数（Kow）
- 2.47
- 分子量
- 201.25
物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。
出典: PubChem · 韓国安全保健公団 SDS
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品179件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Biocide173
- Degradant/impurity (EPA)4
- Processing aids not otherwise specified2
出典: 米国EPA CompTox
関連文献
- Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole. · 2024
- Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection · 2016
- CLSI broth microdilution method for testing susceptibility of Malassezia pachydermatis to thiabendazole · 2009
- The occurrence of thiabendazole‐resistant isolates of Polyscytalum pustulans and Helminthosporium solani on seed potato tubers in relation to fungicide treatment and storage · 1994
- Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice. · 1982