Thiabendazole is a member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2.
定义
Thiabendazole is a member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. It has a role as an antinematodal drug and an antifungal agrochemical. It is a member of benzimidazoles, a member of 1,3-thiazoles and a benzimidazole fungicide. It derives from a hydride of a 1H-benzimidazole.
来源: PubChem
美国FDA 物质登记 · UNII N1Q45E87DT · 登记名称 Thiabendazole · 单一化学物质
化妆品中的作用
安全与法规参考
- 禁用
- 东盟
来源: 东盟化妆品指令
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 148-79-8
- EC No.欧盟化学品目录编号
- 205-725-8
- DTXSID美国EPA化学品编号
- DTXSID0021337
- DTXCID美国EPA化合物编号
- DTXCID401337
- IUPAC
- 2-(1,3-Thiazol-4-yl)-1H-1,3-benzimidazole
- 分子式
- C10H7N3S
- 分子量
- 201.25 g/mol
实测物性
- 性状
- Thiabendazole appears as white or cream-colored odorless, tasteless powder. Sublimes above 590 °F. Fluoresces in acidic solution. Formulated as a dust, flowable powder or wettable powder for use as a systemic fungicide and anthelmintic. · Colorless, white, or tan odorless solid, [HSDB] Colorless solid, [EPA REDs] Off-white to yellow-tan solid, [CPSQ]
- 气味
- Odorless · 无臭
- 熔点
- 579 to 581 °F (NTP, 1992) · 300 °C
- 溶解性
- less than 1 mg/mL at 70 °F (NTP, 1992) · 50 mg/L (at 25 °C)
- 密度
- Amber liquid, density: 1.103 at 25 °C /Thiabendazole hypophosphite/
- 稳定性
- Non-volatile at room temp, stable in water and in acid and alkaline soln, stable under normal conditions to hydrolysis, light, and heat.
- 解离常数
- 4.64 (at 25 °C) · pKa = 4.64
- 熔点/凝固点
- 304~305 ℃
- 溶解度
- 50 ㎎/ℓ (25℃)
- 正辛醇/水分配系数（Kow）
- 2.47
- 分子量
- 201.25
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 179 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Biocide173
- Degradant/impurity (EPA)4
- Processing aids not otherwise specified2
来源: 美国EPA CompTox
相关文献
- Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole. · 2024
- Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection · 2016
- CLSI broth microdilution method for testing susceptibility of Malassezia pachydermatis to thiabendazole · 2009
- The occurrence of thiabendazole‐resistant isolates of Polyscytalum pustulans and Helminthosporium solani on seed potato tubers in relation to fungicide treatment and storage · 1994
- Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice. · 1982