Lipoic acid is a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
How much products actually contain
No product states its amount yet.
Of the products containing it, 8 list it before the 1% line and 43 after it (usually 1% or less).
Products using this ingredient
12 of 51 confirmed · likeliest to carry enough first · See all 51
TheradermPink Magic Cream
TheradermSilky Nude Sunblock
CNP LaboratoryAfter Ray Tone-Up Protection Sun 50ml
CNP LaboratoryAfter-Ray Tone Up Protection Sun
Centellian24Madeca Mela Capture Ampoule Max 15ml (2-Pack)
Centellian24Expert Madeca Mela Capture Ampoule Max 15ml
Centellian24Expert Madeca Mela Capture Ampoule Max 30ml
KlardieCell-Up Diamond Solution
numbuzinnumbuzin No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate
Ole HenriksenOle Henriksen Truth Serum
SIORÉNMN Intensive Serum
EltaMDEltaMD PM Restore Moisturizer
Definition
Lipoic acid is a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position. It has a role as a geroprotector and a fundamental metabolite. It is a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a lipoate.
Source: PubChem
US FDA substance register · UNII 73Y7P0K73Y · registered name ALPHA LIPOIC ACID · single chemical substance
Cosmetic roles
Safety & regulatory references
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.01 g
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.01 g
Source: MFDS (Korea) cosmetic regulatory information
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name チオクト酸: 本品は、次の化学式で表される含硫複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 1077-28-7
- EC No.EU chemical inventory number
- 214-071-2
- DTXSIDUS EPA chemical ID
- DTXSID7025508
- DTXCIDUS EPA compound ID
- DTXCID705508
- IUPAC
- 5-(1,2-Dithiolan-3-yl)pentanoic acid
- Molecular formula
- C8H14O2S2
- Molecular weight
- 206.32 g/mol
Measured properties
- Appearance
- yellow needles from cyclohexane
- Melting/freezing point
- 60~61 ℃
- Initial boiling point and range
- 160~165 ℃
- Water solubility
- 126.6 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 3.40
- Molecular weight
- 206.34
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant2
Source: US EPA CompTox dashboard
Related literature
- Sustainable Poly Thioctic Acid‐Based Elastomer for Super‐Stretchable Electronic Sensors · 2025
- Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders · 2025
- Biomimetic poly(thioctic acid)-based bioadhesive hydrogels for wet adhesion, expeditious hemostasis and enhanced wound healing. · 2024
- A gentamicin-thioctic acid multifunctional hydrogel for accelerating infected wound healing. · 2022
- Antibacterial, wearable, transparent tannic acid-thioctic acid-phytic acid hydrogel for adhesive bandages. · 2022
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese