Ingredient Dictionary

THIODIGLYCOL

Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom.

Definition

Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol.

Source: PubChem

US FDA substance register · UNII 9BW5T43J04 · registered name THIODIGLYCOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

THIODIGLYCOLINCI티오다이글라이콜Korean label name (MFDS standard)Ethanol, 2,2'-thiobis-Synonym

CAS No.chemical registry number: 111-48-8
EC No.EU chemical inventory number: 203-874-3
DTXSIDUS EPA chemical ID: DTXSID6026878
DTXCIDUS EPA compound ID: DTXCID506878

IUPAC: 2,2'-Sulfanediyldi(ethan-1-ol)
Molecular formula: C4H10O2S
Molecular weight: 122.18 g/mol

Measured properties

Appearance: This material has many uses, including as a precursor to the sulfur mustard family of chemical weapons. It is chemically similar to thioglycol and is expected to react in a similar way to this material. See the chemical datasheet for thioglycol for more information. · Liquid
Odour: Characteristic odor · Odor similar to hydrogen sulfide
Boiling point: 282 °C · 282.00 °C. @ 760.00 mm Hg
Melting point: -10.2 °C · -18 - -10 °C
Solubility: In water, miscible at 20 °C · Miscible with water
Density: 1.1793 g/cu cm at 25 °C · Bulk density: 9.85 lb/gal
Stability: Stable under recommended storage conditions.
Viscosity: 0.652 cP at 20 °C · (0.652P)
Melting/freezing point: -10.2 ℃
Initial boiling point and range: 283 ℃
Flash point: 160 ℃(o.c.)
Upper/lower flammability or explosive limits: 5.2 / 1.2 %
Vapour pressure: 0.00323 ㎜Hg (25℃)
Water solubility: 100 g/100㎖ (20℃)
Vapour density: 4.22
Relative density: 1.1852
n-Octanol/water partition coefficient (Kow): -0.63
Auto-ignition temperature: 260 ℃
Molecular weight: 122.18

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Intermediate1
Binder1
Antioxidant1
Solvent1
Processing aids not otherwise specified1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 5 eye studies are on record.

Classed as low5

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 10 studies

Not classified
Skin Irritation · Screening
Not classified
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Not classified
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to