Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom.
定義
Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol.
出典: PubChem
米国FDA 物質登録 · UNII 9BW5T43J04 · 登録名 THIODIGLYCOL · 単一の化学物質
化粧品での役割
安全性・規制情報
韓国の有害物質GHS分類なし · 既存化学物質
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
- CAS No.化学物質登録番号
- 111-48-8
- EC No.EU化学物質目録番号
- 203-874-3
- DTXSID米国EPA化学物質番号
- DTXSID6026878
- DTXCID米国EPA化合物番号
- DTXCID506878
- IUPAC
- 2,2'-Sulfanediyldi(ethan-1-ol)
- 分子式
- C4H10O2S
- 分子量
- 122.18 g/mol
測定された物性
- 性状
- This material has many uses, including as a precursor to the sulfur mustard family of chemical weapons. It is chemically similar to thioglycol and is expected to react in a similar way to this material. See the chemical datasheet for thioglycol for more information. · Liquid
- 臭い
- Characteristic odor · Odor similar to hydrogen sulfide
- 沸点
- 282 °C · 282.00 °C. @ 760.00 mm Hg
- 融点
- -10.2 °C · -18 - -10 °C
- 溶解性
- In water, miscible at 20 °C · Miscible with water
- 密度
- 1.1793 g/cu cm at 25 °C · Bulk density: 9.85 lb/gal
- 安定性
- Stable under recommended storage conditions.
- 粘度
- 0.652 cP at 20 °C · (0.652P)
- 融点・凝固点
- -10.2 ℃
- 初留点および沸点範囲
- 283 ℃
- 引火点
- 160 ℃(o.c.)
- 燃焼・爆発範囲の上限/下限
- 5.2 / 1.2 %
- 蒸気圧
- 0.00323 ㎜Hg (25℃)
- 溶解度
- 100 g/100㎖ (20℃)
- 蒸気密度
- 4.22
- 比重
- 1.1852
- n-オクタノール/水分配係数（Kow）
- -0.63
- 自然発火温度
- 260 ℃
- 分子量
- 122.18
物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。
出典: PubChem · 韓国安全保健公団 SDS
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品5件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Intermediate1
- Binder1
- Antioxidant1
- Solvent1
- Processing aids not otherwise specified1
出典: 米国EPA CompTox
刺激・感作試験の記録
皮膚試験5件・眼試験5件の記録があります。
試験の結論はおおむね一致しています（100%）。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験10件をすべて見る
- Not classified
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Not classified
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
出典: 米国EPA CompTox
関連文献
- Monitoring Urine Thiodiglycol after Rabbit Skin Exposure to Sulfur Mustard Based on Highly-sensitive Isotope Dilution Gas Chromatography-Mass Spectrometry · 2014
- Application of in vivo microdialysis for studying the efficacy of protective preparations against sulfur mustard penetrating the skin · 2008
- Toxicity Assessment of Thiodiglycol · 2005
- Quantitative analysis of the sulfur mustard hydrolysis product thiodiglycol (2,2'-sulfobisethanol) in in vivo microdialysates using gas chromatography coupled with pulsed flame photometric detection. · 2005
- QUANTIFICATION OF THIODIGLYCOL IN HUMAN URINE AFTER AN ACCIDENTAL SULFUR MUSTARD EXPOSURE · 2000