Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom.
定义
Thiodiglycol is a diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom. It has a role as an antioxidant, a metabolite, an antineoplastic agent and a solvent. It is an aliphatic sulfide and a diol. It is functionally related to a mercaptoethanol.
来源: PubChem
美国FDA 物质登记 · UNII 9BW5T43J04 · 登记名称 THIODIGLYCOL · 单一化学物质
化妆品中的作用
延缓产品因氧化变质ANTIOXIDANT
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
THIODIGLYCOLINCI티오다이글라이콜韩国标示名称（食药处标准名）Ethanol, 2,2'-thiobis-同义名
- CAS No.化学物质登记号
- 111-48-8
- EC No.欧盟化学品目录编号
- 203-874-3
- DTXSID美国EPA化学品编号
- DTXSID6026878
- DTXCID美国EPA化合物编号
- DTXCID506878
- IUPAC
- 2,2'-Sulfanediyldi(ethan-1-ol)
- 分子式
- C4H10O2S
- 分子量
- 122.18 g/mol
实测物性
- 性状
- This material has many uses, including as a precursor to the sulfur mustard family of chemical weapons. It is chemically similar to thioglycol and is expected to react in a similar way to this material. See the chemical datasheet for thioglycol for more information. · Liquid
- 气味
- Characteristic odor · Odor similar to hydrogen sulfide
- 沸点
- 282 °C · 282.00 °C. @ 760.00 mm Hg
- 熔点
- -10.2 °C · -18 - -10 °C
- 溶解性
- In water, miscible at 20 °C · Miscible with water
- 密度
- 1.1793 g/cu cm at 25 °C · Bulk density: 9.85 lb/gal
- 稳定性
- Stable under recommended storage conditions.
- 黏度
- 0.652 cP at 20 °C · (0.652P)
- 熔点/凝固点
- -10.2 ℃
- 初沸点和沸程
- 283 ℃
- 闪点
- 160 ℃(o.c.)
- 燃烧或爆炸范围上限/下限
- 5.2 / 1.2 %
- 蒸气压
- 0.00323 ㎜Hg (25℃)
- 溶解度
- 100 g/100㎖ (20℃)
- 蒸气密度
- 4.22
- 比重
- 1.1852
- 正辛醇/水分配系数（Kow）
- -0.63
- 自燃温度
- 260 ℃
- 分子量
- 122.18
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 5 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Intermediate1
- Binder1
- Antioxidant1
- Solvent1
- Processing aids not otherwise specified1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 5 项、眼部试验 5 项。
归类为低5 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 10 项试验
- Not classified
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Not classified
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
来源: 美国EPA CompTox
相关文献
- Monitoring Urine Thiodiglycol after Rabbit Skin Exposure to Sulfur Mustard Based on Highly-sensitive Isotope Dilution Gas Chromatography-Mass Spectrometry · 2014
- Application of in vivo microdialysis for studying the efficacy of protective preparations against sulfur mustard penetrating the skin · 2008
- Toxicity Assessment of Thiodiglycol · 2005
- Quantitative analysis of the sulfur mustard hydrolysis product thiodiglycol (2,2'-sulfobisethanol) in in vivo microdialysates using gas chromatography coupled with pulsed flame photometric detection. · 2005
- QUANTIFICATION OF THIODIGLYCOL IN HUMAN URINE AFTER AN ACCIDENTAL SULFUR MUSTARD EXPOSURE · 2000