Definition
US FDA substance register · UNII GYV9AM2QAG · registered name Thiourea · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 321
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/321
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name チオ尿素: 本品は、次の化学式で表される化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 62-56-6
- EC No.EU chemical inventory number
- 200-543-5
- DTXSIDUS EPA chemical ID
- DTXSID9021348
- DTXCIDUS EPA compound ID
- DTXCID101348
- IUPAC
- Thiourea
- Molecular formula
- CH4N2S
- Molecular weight
- 76.12 g/mol
Measured properties
- Odour
- odourless
- Melting/freezing point
- 182 ℃
- Vapour pressure
- 0.0028 ㎜Hg (25℃)
- Water solubility
- 14.2 g/100㎖ (25℃)
- Relative density
- 1.405
- n-Octanol/water partition coefficient (Kow)
- -1.08
- Molecular weight
- 76.1
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide2
- Surfactant (surface active agent)2
- Surface modifier1
- Humectant1
- Fuel1
- Leaching agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
9 skin studies and 4 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 13 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to other guideline: Entwurf der Prufungsvorschrift OECD Short term toxicology group, acute dermal irritation/corrosivity (31.12.1979) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not classified
Skin Irritation · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 1
Skin Sensitization · Screening - Sh
Skin Sensitization · Authoritative - Ambiguous
skin irritation: in vivo · Screening · other guideline: OECD 402 equivalent or similar to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Category 2B
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: Entwurf der Prufungsvorschrift der OECD "Short term toxicology group, Acute eye irritation/corrosivity" vom 31.12.1979 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: Techniques as published by the FDA of the US (Fed. Reg. (119), 5582, 1963) and Draize and Kelley (Drug Cosmet. Industr. 71 (1952) 36) according to
Source: US EPA CompTox dashboard
Related literature
- Design and computational study of the thiourea–cobalt(III) complex as an anticancer candidate · 2023
- Changes in thyroid histomorphology and thyroglobulin immunostaining upon exposure to thiourea in Triturus newts. · 2022
- Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors · 2015
- Chemical Treatment of Thiourea in Acidic Cleaning Wastes · 1990
- Thiourea as a House Fly Larvicide in Caged Laying Hen Manure: Topical and Feed-Through Administration · 1988
Linked databases 25
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese