Ingredient Dictionary

THIRAM

Thiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid.

Definition

Thiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment. It has a role as an antibacterial drug, an antiseptic drug and an antifungal agrochemical. It contains a dimethyldithiocarbamate. It is functionally related to a dimethyldithiocarbamic acid.

Source: PubChem

US FDA substance register · UNII 0D771IS0FH · registered name THIRAM · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Inhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Banned: ASEAN · European Union · Taiwan · United Kingdom
Restricted or banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Canada

Conditions of Use by product type : Latex products
Maximum Concentration Permitted : 14%

Japan

Maximum amount per 100 g(Maximum amount of ingredient per 100 g) : (a) 0.50 g (b) 0.30g

Source: MFDS (Korea) cosmetic regulatory information

Korea’s toxic-substance GHS classification: Warning · H315 (category 2) · H302 (category 4) · H332 (category 4) · +5 more

Source: Korea toxic substances GHS register (NIER)

Restriction II/162

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

THIRAMINCI티람Korean label name (MFDS standard)Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N′,N′-tetramethyl-Synonym

CAS No.chemical registry number: 137-26-8
EC No.EU chemical inventory number: 205-286-2
DTXSIDUS EPA chemical ID: DTXSID5021332
DTXCIDUS EPA compound ID: DTXCID401332

Molecular formula: C6H12N2S4
Molecular weight: 240.42 g/mol

Measured properties

Appearance: Thiram appears as a liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways. · Large Crystals, Dry Powder, Other Solid
Odour: Characteristic odor
Boiling point: 264 °F at 20 mmHg (NTP, 1992) · 129 °C at 20 mm Hg
Melting point: 311 to 313 °F (NTP, 1992) · 155-156 °C
Solubility: less than 1 mg/mL at 72 °F (NTP, 1992) · Solubility in alcohol and in ether less than 0.2%, solubility in acetone 1.2%, in benzene 2.5%.
Density: 1.43 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.3 g/cu cm
Stability: Decomposed in acidic media. Some deterioration on prolonged exposure to heat, air or moisture. DT50 (est.) (22 °C) 128 days (pH 4), 18 days (pH 7), 9 hr (pH 9).
pH: 6.75 (4 vol%, 20℃ (EPA OPPTS 830.7000))
Melting/freezing point: 144~146 ℃ ((EU Method A.1, GLP))
Initial boiling point and range: 129 ℃(20 mmHg)
Flammability (solid, gas): EU Method A.10, GLP
Vapour pressure: 0.0000172 ㎜Hg (25℃)
Water solubility: 0.017 (20 °C, pH=7 (OECD TG 105, GLP), g/L)
Relative density: 1.36 g/cm³ (20℃ (EU Method A.3, GLP))
n-Octanol/water partition coefficient (Kow): 1.73
Auto-ignition temperature: 250 ℃
Molecular weight: 240.44

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 32 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Biocide8
Chemical reaction regulator8
Catalyst7
Polymerization promoter3
Processing aids not otherwise specified2
Preservative1
Hardener1
Elasticizer1

1 other uses

Dispersing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

10 skin studies and 5 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 15 studies

Skin Irrit. 2
Skin Irritation · Authoritative
Sh
Skin Sensitization · Authoritative
Skin Sens. 1
Skin Sensitization · Screening
Skin Irrit. 2
Skin Irritation · Screening
Category 1A
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPP 81-6 (Skin Sensitisation)
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Skin Sens. 1
Skin Sensitization · Authoritative
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2A
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Severe Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
Eye Irrit. 2
Eye Irritation · Screening