Thymol is a phenol that is a natural monoterpene derivative of cymene.
How much products actually contain
No product states its amount yet.
Of the products containing it, 5 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
6 of 6 confirmed · likeliest to carry enough first
Definition
Thymol is a phenol that is a natural monoterpene derivative of cymene. It has a role as a volatile oil component. It is a monoterpenoid and a member of phenols. It derives from a hydride of a p-cymene.
Source: PubChem
US FDA substance register · UNII 3J50XA376E · registered name Thymol · single chemical substance
Thymol is the substituted phenol that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.050 g
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.050 g
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Final Report on the Safety Assessment of Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols, m-Cresol, o-Cresol, p-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name チモール: 本品は、フェノール（＊）の誘導体であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 89-83-8
- EC No.EU chemical inventory number
- 201-944-8
- DTXSIDUS EPA chemical ID
- DTXSID6034972
- DTXCIDUS EPA compound ID
- DTXCID4014972
- IUPAC
- 5-Methyl-2-(propan-2-yl)phenol
- Molecular formula
- C10H14O
- Molecular weight
- 150.221 g/mol
Measured properties
- Appearance
- Other Solid · Colorless or white solid with an herbal odor like thyme, [HSDB] White crystalline solid with an odor like phenol, [MSDSonline]
- Odour
- Odor of thyme · A spicy-herbal, slightly medicinal odor reminiscent of thyme
- Boiling point
- 232.5 °C · 233 °C
- Melting point
- 51.5 °C · 49.6 °C
- Solubility
- 900 mg/L (at 20 °C) · In water, 900 mg/L at 20 °C
- Density
- 0.9699 g/cu cm at 25 °C · 0.972 @25 °C
- Stability
- Appreciably volatile at 100 °C, volatilizes in water vapors. · Stable under recommended storage conditions.
- pH
- Solution in alcohol is neutral to litmus · 10.62 (pKa)
- Dissociation constant
- 10.6 (at 20 °C) · pKa = 10.62
- Melting/freezing point
- 49 ℃
- Initial boiling point and range
- 233 ℃
- Flash point
- 104 ℃
- Vapour pressure
- 0.0601 ㎜Hg
- Water solubility
- 1000 ㎎/ℓ
- Relative density
- 0.970
- n-Octanol/water partition coefficient (Kow)
- 3.3
- Molecular weight
- 150.21
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance8
- Biocide5
- Dye3
- Flavouring and nutrient2
- Deodorizer2
- Processing aids not otherwise specified1
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- Skin Corr. 1B
Skin Irritation · Authoritative - Category 1
Skin Irritation · Screening - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Classification not possible
Skin Sensitization · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Formulation and Evaluation of Microemulsion of Curcumin in Thymol-Menthol Carrier System · 2021
- Fabrication of Caseinate Stabilized Thymol Nanosuspensions via the pH-Driven Method: Enhancement in Water Solubility of Thymol · 2021
- Thymol provokes burst of action potentials in neurons of snail Caucasotachea atrolabiata. · 2020
- Pharmacokinetic study of thymol after intravenous injection and high‐dose inhalation in mouse model · 2019
- Thymol, thyme, and other plant sources: Health and potential uses · 2018
Linked databases 23
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI 2
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese