Ingredient Dictionary

TOLNAFTATE

Tolnaftate is a monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol.

Definition

Tolnaftate is a monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm. It has a role as an antifungal drug. It is functionally related to a 2-naphthol.

Source: PubChem

US FDA substance register · UNII 06KB629TKV · registered name TOLNAFTATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Inhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Banned: Canada

Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

More data — names, identifiers, properties, test records, literature

Names & identifiers

TOLNAFTATEINCI톨나프테이트Korean label name (MFDS standard)

CAS No.chemical registry number: 2398-96-1
EC No.EU chemical inventory number: 219-266-6
DTXSIDUS EPA chemical ID: DTXSID3042477
DTXCIDUS EPA compound ID: DTXCID1022477

IUPAC: O-(Naphthalen-2-yl) methyl(3-methylphenyl)carbamothioate
Molecular formula: C19H17NOS
Molecular weight: 307.41 g/mol

Measured properties

Appearance: Crystals or white powder. (NTP, 1992) · Solid
Melting point: 230.9 to 232.7 °F (NTP, 1992) · 111 °C
Solubility: less than 1 mg/mL at 72 °F (NTP, 1992) · 0.0000702 mg/mL at 25 °C
Melting/freezing point: 111 ℃
Molecular weight: 307.42

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Biocide2
No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across