TOLUENE-2,5-DIAMINE SULFATE

2,5-diaminotoluene sulfate is an organic sulfate salt obtained by combining 2,5-diaminotoluene with one molar equivalent of sulfuric acid; occurs as an intermediate during hair dye formulation. It has a role as an allergen. It is a diamine and an organic sulfate salt. It is functionally related to a 2-methyl-1,4-phenylenediamine.

Source: PubChem

US FDA substance register · UNII 8PSD05SPE2 · registered name 2,5-DIAMINOTOLUENE SULFATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Restricted

South Korea

Source: MFDS (Korea) cosmetic regulatory information

ASEAN

• Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
• Other limitations and requirements : 1. and 2. After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
• Conditions of use and warning which must be printed on the labels : To be printed on the label: The mixing ratio “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. Contains phenylenediamines. (toluene diamines). Do not use to dye eyelashes or eyebrows.”

Canada

• Conditions of Use by product type : (a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations. (b) In hair dyes as indicated in section 22 of the Cosmetic Regulations.
• Warnings and Cautionary Statements: (to the effect of) : On the inner label and the outer label of the cosmetic:“CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness.” Instructions to the following effect accompany each package of hair dye: (i) The preparation may cause serious inflammation of the skin in some persons, and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and (ii) To make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye, as prepared for use, should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.”

Taiwan

• 3.6%

China

• Maximum concentration : 4.0%

European Union

• Product Type, body parts : Hair dye substance in oxidative hair dye products (a) General use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration to hair must not exceed 4% calculated as free base.
• Other : (a) and (b) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
• Wording of conditions of use and warnings : (a) Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Do not use to dye eyelashes or eyebrows. The mixing ratio is printed on the label (b) For professional use only Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Wear suitable gloves. The mixing ratio is printed on the label

Korea’s toxic-substance GHS classification: Danger · H312 (category 4) · H332 (category 4) · H317 (category 1) · +2 more

Source: Korea toxic substances GHS register (NIER)

Restriction III/9a · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Toluene-2,5-diamine

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-Diamine as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)