2,5-diaminotoluene sulfate is an organic sulfate salt obtained by combining 2,5-diaminotoluene with one molar equivalent of sulfuric acid; occurs as an intermediate during hair dye formulation.
- Límite en Corea
- 3.6%
Definición
2,5-diaminotoluene sulfate is an organic sulfate salt obtained by combining 2,5-diaminotoluene with one molar equivalent of sulfuric acid; occurs as an intermediate during hair dye formulation. It has a role as an allergen. It is a diamine and an organic sulfate salt. It is functionally related to a 2-methyl-1,4-phenylenediamine.
Fuente: PubChem
Registro de sustancias de la FDA (EE. UU.) · UNII 8PSD05SPE2 · nombre registrado 2,5-DIAMINOTOLUENE SULFATE · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Restringido
- Corea del Sur
Fuente: Información regulatoria cosmética del MFDS (Corea)
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : 1. and 2. After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
- Conditions of use and warning which must be printed on the labels : To be printed on the label: The mixing ratio “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. Contains phenylenediamines. (toluene diamines). Do not use to dye eyelashes or eyebrows.”
Canadá
- Conditions of Use by product type : (a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations. (b) In hair dyes as indicated in section 22 of the Cosmetic Regulations.
- Warnings and Cautionary Statements: (to the effect of) : On the inner label and the outer label of the cosmetic:“CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness.” Instructions to the following effect accompany each package of hair dye: (i) The preparation may cause serious inflammation of the skin in some persons, and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and (ii) To make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye, as prepared for use, should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.”
Taiwán
- 3.6%
China
- Concentración máxima : 4.0%
Unión Europea
- Product Type, body parts : Hair dye substance in oxidative hair dye products (a) General use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration to hair must not exceed 4% calculated as free base.
- Other : (a) and (b) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
- Wording of conditions of use and warnings : (a) Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Do not use to dye eyelashes or eyebrows. The mixing ratio is printed on the label (b) For professional use only Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Wear suitable gloves. The mixing ratio is printed on the label
Fuente: Información regulatoria cosmética del MFDS (Corea)
Clasificación GHS de sustancias tóxicas de Corea: Peligro · H312 (categoría 4) · H332 (categoría 4) · H317 (categoría 1) · y 2 más
Restriction III/9a · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on Toluene-2,5-diamine
Reviewed by CIR: Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine
Reviewed by CIR: Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-Diamine as Used in Cosmetics
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 615-50-9
- CAS No.número de registro químico
- 6369-59-1
- EC No.número de inventario químico de la UE
- 210-431-8
- EC No.número de inventario químico de la UE
- 228-871-4
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID50872532
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID90405
- IUPAC
- 2-Methylbenzene-1,4-bis(aminium) sulfate
- Fórmula molecular
- C7H12N2O4S
- Peso molecular
- 220.24 g/mol
Propiedades medidas
- Aspecto
- 2,5-toluenediamine sulfate is a light tan to light purple powder. (NTP, 1992) · Off-white solid, [HSDB] Light tan to light purple solid, [CAMEO]
- Punto de fusión
- 40.6 °C
- Solubilidad
- less than 1 mg/mL at 68 °F (NTP, 1992) · In water, 5.03 g/L at 20 °C
- Densidad
- 1.366 g/mL at 20 °C
- pH
- pH = 2.47, 20 °C, saturated aqueous solution
- Constante de disociación
- pKa1 = 6.39, pKa2 = 2.77 (calculated)
- Punto de fusión/congelación
- 40.6 ℃
- Solubilidad en agua
- 5.03 g/ℓ
- Densidad relativa
- 1366
- Coeficiente de reparto n-octanol/agua (Kow)
- 0.74
- Peso molecular
- 220.3
Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.
Fuente: PubChem · Fichas de datos de seguridad de KOSHA (Corea)
Para qué lo usan los productos
Usos de los 1 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye1
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 3 estudios en piel y 1 en ojos.
Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 4 estudios
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Skin Sens. 1
Skin Sensitization · Authoritative - Moderate or Mild Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: HET CAM in vitro method equivalent or similar to
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Analysis of the Integration of Vegan Formulas into Eyelash Extension Materials and Eyebrow Dyes: Chemical Stability and Allergy Minimization in Accordance with Updated FDA Regulations for 2025 · 2025
- Contact Allergens in “PPD-Free” Hair Dyes · 2025
- Allergic contact dermatitis caused by 4‐n‐butylresorcinol present in a night cream for skin hyperpigmentation · 2020
- Clinical Profile and Allergens in Pigmented Cosmetic Dermatitis and Allergic Contact Dermatitis to Cosmetics in India · 2018
- Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine · 2016
Bases de datos vinculadas 20
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- ChEBI
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Fichas de datos de seguridad de KOSHA (Corea)
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Informes del Programa Nacional de Toxicología (EE. UU.)
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- Lista de ingredientes restringidos de Health Canada
- Panel CompTox de la EPA 2
- PubChem 2
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Wikidata