2-methyl-1,4-phenylenediamine is a diamine in which the two amino groups are substituted into toluene at the 2- and 5-positions.
- Límite en Corea
- 2.0%
Definición
2-methyl-1,4-phenylenediamine is a diamine in which the two amino groups are substituted into toluene at the 2- and 5-positions. It has a role as an allergen. It derives from a hydride of a toluene.
Fuente: PubChem
Registro de sustancias de la FDA (EE. UU.) · UNII 24JO8Z0RJU · nombre registrado TOLUENE-2,5-DIAMINE · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Restringido
- Corea del Sur · Reino Unido
Fuente: Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Lista de ingredientes restringidos de Health Canada · Información regulatoria cosmética del MFDS (Corea) · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : 1. and 2. After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
- Conditions of use and warning which must be printed on the labels : To be printed on the label: The mixing ratio “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. Contains phenylenediamines. (toluene diamines). Do not use to dye eyelashes or eyebrows.”
Canadá
- Conditions of Use by product type : (a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations. (b) In hair dyes as indicated in section 22 of the Cosmetic Regulations.
- Warnings and Cautionary Statements: (to the effect of) : On the inner label and the outer label of the cosmetic:“CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness.” Instructions to the following effect accompany each package of hair dye: (i) The preparation may cause serious inflammation of the skin in some persons, and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and (ii) To make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye, as prepared for use, should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.”
Taiwán
- 3.6%
China
- Concentración máxima : 4%
Unión Europea
- Product Type, body parts : Hair dye substance in oxidative hair dye products (a) General use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration to hair must not exceed 4% calculated as free base.
- Other : (a) and (b) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
- Wording of conditions of use and warnings : (a) Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Do not use to dye eyelashes or eyebrows. The mixing ratio is printed on the label (b) For professional use only Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Wear suitable gloves. The mixing ratio is printed on the label
Fuente: Información regulatoria cosmética del MFDS (Corea)
Clasificación GHS de sustancias tóxicas de Corea: Peligro · H332 (categoría 4) · H301 (categoría 3) · H411 (categoría 2) · y 2 más
Restriction III/9a · SCCS opinion: Opinion on Toluene-2 5-diamine and its sulfate; Opinion on Toluene-2,5-diamine
Reviewed by CIR: Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine
Reviewed by CIR: Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-Diamine as Used in Cosmetics
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 95-70-5
- EC No.número de inventario químico de la UE
- 202-442-1
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID6029123
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID707869
- IUPAC
- 2-Methylbenzene-1,4-diamine
- Fórmula molecular
- C7H10N2
- Peso molecular
- 122.171 g/mol
Propiedades medidas
- Aspecto
- Other Solid · Colorless plates, [HSDB]
- Punto de ebullición
- 273.5 °C
- Punto de fusión
- 64 °C
- Solubilidad
- Soluble in water, ethanol, ethyl ether, slightly soluble in benzene, acetic acid
- Color
- incoloro
- Punto de fusión/congelación
- 64 ℃
- Punto inicial e intervalo de ebullición
- 273.5 ℃
- Punto de inflamación
- 140 ℃
- Presión de vapor
- 0.0037 ㎜Hg
- Solubilidad en agua
- 72500 ㎎/ℓ
- Coeficiente de reparto n-octanol/agua (Kow)
- 0.16
- Peso molecular
- 122.17
Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.
Fuente: PubChem · Fichas de datos de seguridad de KOSHA (Corea)
Para qué lo usan los productos
Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye3
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 7 estudios en piel y 3 en ojos.
Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 10 estudios
- Skin Sens. 1
Skin Sensitization · Authoritative - Category 1
Skin Sensitization · Screening - Sh
Skin Sensitization · Authoritative - Category 3
Skin Irritation · Screening - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) Magnusson and Kligman - Ambiguous
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to other guideline: Code of Federal Regulations, Title 16, Section 1500.41 according to - Category 2A-2B
Eye Irritation · Screening - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Severe Hair Dye Anaphylaxis Caused by Toluene-2,5- Diamine Identified by Positive in Vitro Tests. · 2026
- Contact Allergy to Hair Dyes · 2016
- Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine as Used in Cosmetics · 2010
- Toluene‐2,5‐diamine may be an isolated allergy in individuals sensitized by permanent hair dye · 2007
- Allergic contact dermatitis from toluene‐2,5‐diamine in a cream dye for eyelashes and eyebrows – quantitative exposure assessment · 2007
Bases de datos vinculadas 28
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- ChEBI
- Clasificación de carcinógenos de la IARC
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Dictámenes de seguridad del SCCS (UE)
- Directiva cosmética de la ASEAN
- Fichas de datos de seguridad de KOSHA (Corea)
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Ingredientes cosméticos de la FDA de Taiwán
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- Lista de ingredientes restringidos de Health Canada
- NIST Chemistry WebBook
- Normativa cosmética de la FDA de Taiwán
- Normativa cosmética del Reino Unido (OPSS)
- Panel CompTox de la EPA 2
- PubChem 2
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Reglamento de cosméticos de la UE
- Wikidata
- Wikipedia · inglés · japonés