TOLUENE-2,5-DIAMINE

2-methyl-1,4-phenylenediamine is a diamine in which the two amino groups are substituted into toluene at the 2- and 5-positions. It has a role as an allergen. It derives from a hydride of a toluene.

来源: PubChem

美国FDA 物质登记 · UNII 24JO8Z0RJU · 登记名称 TOLUENE-2,5-DIAMINE · 单一化学物质

来源: 美国FDA 物质识别码（UNII）

限用

韩国 · 英国

来源: 东盟化妆品指令 · 欧盟化妆品法规 · 加拿大禁用·限用成分清单 · 韩国食药处 化妆品法规信息 · 台湾FDA 化妆品成分 · 台湾FDA 化妆品法规 · 英国化妆品法规

东盟

• Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
• Other limitations and requirements : 1. and 2. After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
• Conditions of use and warning which must be printed on the labels : To be printed on the label: The mixing ratio “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary ‘black henna’ tattoo in the past. Contains phenylenediamines. (toluene diamines). Do not use to dye eyelashes or eyebrows.”

加拿大

• Conditions of Use by product type : (a) Not permitted in the area of the eye as indicated in section 14 of the Cosmetic Regulations. (b) In hair dyes as indicated in section 22 of the Cosmetic Regulations.
• Warnings and Cautionary Statements: (to the effect of) : On the inner label and the outer label of the cosmetic:“CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so may cause blindness.” Instructions to the following effect accompany each package of hair dye: (i) The preparation may cause serious inflammation of the skin in some persons, and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and (ii) To make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye, as prepared for use, should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.”

台湾

• ※ 染髮產品之限量標準：係指該成分依產品使用說明書混合後之最高允許使用量。
• ※ 化粧品之外包裝或容器，應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者，應於標籤、仿單或以其他方式刊載之。
• ※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
• ※ 化粧品宣稱效能者，須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
• 用途 : 使用限制
• 最大配合量 : 氧化性染髮產品 : 2% (以free base 計)
• 3.6% (以sulfate salt 計)
• 3.6%

中国

• 最大配合量 : 4%

欧盟

• Product Type, body parts : Hair dye substance in oxidative hair dye products (a) General use (b) Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration to hair must not exceed 4% calculated as free base.
• Other : (a) and (b) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 4% calculated as free base
• Wording of conditions of use and warnings : (a) Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Do not use to dye eyelashes or eyebrows. The mixing ratio is printed on the label (b) For professional use only Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary "black henna" tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporay "black henna" tattoo in the past. Contains phenylenediamines (toluenediamines). Wear suitable gloves. The mixing ratio is printed on the label

韩国有毒物质 GHS 分类: 危险 · H332 (第4类) · H301 (第3类) · H411 (第2类) · 另有 2 项

来源: 韩国有毒物质 GHS 信息（环境公团）

Restriction III/9a · SCCS opinion: Opinion on Toluene-2 5-diamine and its sulfate; Opinion on Toluene-2,5-diamine

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Report on the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine

来源: 美国CIR 安全性评估

Reviewed by CIR: Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-Diamine as Used in Cosmetics

来源: 美国CIR 安全性评估