Definition
US FDA substance register · UNII BF6E9O0XJN · registered name 1,1,3-TRI(3-TERT-BUTYL-4-HYDROXY-6-METHYLPHENYL)BUTANE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1843-03-4
- EC No.EU chemical inventory number
- 217-420-7
- DTXSIDUS EPA chemical ID
- DTXSID0038883
- DTXCIDUS EPA compound ID
- DTXCID8018883
- IUPAC
- 4,4',4''-(Butane-1,1,3-triyl)tris(2-tert-butyl-5-methylphenol)
- Molecular formula
- C37H52O3
- Molecular weight
- 544.82 g/mol
Measured properties
- Appearance
- Liquid, Dry Powder
- Colour
- white
- Melting/freezing point
- 183~190 ℃
- Flash point
- 107 ℃((c.c))
- Molecular weight
- 544.82
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 20 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant6
- Processing aids not otherwise specified5
- Plasticizer4
- Photosensitive agent1
- Film former1
- Intermediate1
- UV stabilizer1
- Solvent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) according to EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) according to - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants) according to
Source: US EPA CompTox dashboard
Linked databases 13
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata