Tricalcium bis(phosphate) is a calcium phosphate.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 4 after it (usually 1% or less).
Products using this ingredient
5 of 5 confirmed · likeliest to carry enough first
Definition
Tricalcium bis(phosphate) is a calcium phosphate.
Source: PubChem
US FDA substance register · UNII K4C08XP666 · registered name TRICALCIUM PHOSPHATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name リン酸3Ca: 本品は、次の化学式で表されるリン酸(*)のカルシウム塩である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 7758-87-4
- EC No.EU chemical inventory number
- 231-840-8
- DTXSIDUS EPA chemical ID
- DTXSID1049803
- DTXCIDUS EPA compound ID
- DTXCID5029762
- IUPAC
- Calcium phosphate (3/2)
- Molecular formula
- Ca3O8P2
- Molecular weight
- 310.174 g/mol
Measured properties
- Appearance
- Calcium phosphate is an odorless white solid. Sinks and mixes with water. (USCG, 1999) · Dry Powder, Liquid
- Odour
- Odorless · odourless
- Melting point
- >450 · 1670 °C
- Solubility
- 7.7g/L · Practically insoluble in water, insoluble in ethanol, soluble in dilute hydrochloric and nitric acid
- Density
- 2 to 3 at 68 °F (USCG, 1999) · 3.14 g/cu cm
- Stability
- STABLE IN AIR /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/
- Colour
- white
- pH
- 5-7 (at 100g/l 20℃)
- Melting/freezing point
- &, gt, 1000 ℃
- Vapour pressure
- 68 ㎜Hg (at 0℃)
- Water solubility
- &, lt, 1 ㎎/ℓ (at 25℃)
- Vapour density
- 10.7 (air=1)
- Relative density
- 3.14
- Molecular weight
- 310
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 42 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Anti-caking agent7
- Flavouring and nutrient7
- Opacifer5
- Abrasive3
- Dispersing agent2
- Pigment2
- Soil amendments2
- Deodorizer2
12 other uses
- Other1
- Thickening agent1
- Softener and conditioner1
- Drier1
- pH regulating agent1
- Leavening agent (EPA)1
- Filler1
- Humectant1
- Surfactant (surface active agent)1
- Fragrance1
- Processing aids not otherwise specified1
- Emulsifier1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1992 - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Development Status and Application of Tricalcium Phosphate in Oral Clinical Treatment · 2022
- Physical properties and morphology of electrospun composite fiber mats of polyhydroxyalkanoate containing nanoclay and tricalcium phosphate additives · 2018
- Histological Evaluation of Effect of beta-Tricalcium Phosphate on Bone healing in Alloxan-Induced diabetes · 2016
- The irritative property of alpha-tricalcium phosphate to the rabbit skin. · 2009
- Regenerative Repair of Long Intercalated Rib Defects Using Porous Cylinders of &bgr;-Tricalcium Phosphate: An Experimental Study in a Canine Model · 2007
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese