Ingredient Dictionary

TRICHLOROETHANE

1,1,1-Trichloroethane can cause cancer according to California Labor Code.

Definition

1,1,1-Trichloroethane can cause cancer according to California Labor Code.

Source: PubChem

US FDA substance register · UNII 113C650IR1 · registered name TRICHLOROETHANE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer · Related EU regulation: (EC) 2009/1005

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Trichloroethane

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

TRICHLOROETHANEINCI트라이클로로에탄Korean label name (MFDS standard)Ethane, 1,1,1-trichloro-Synonym

CAS No.chemical registry number: 25323-89-1
CAS No.chemical registry number: 71-55-6
EC No.EU chemical inventory number: 200-756-3
DTXSIDUS EPA chemical ID: DTXSID0021381
DTXCIDUS EPA compound ID: DTXCID501381

IUPAC: 1,1,1-Trichloroethane
Molecular formula: C2H3Cl3
Molecular weight: 133.4 g/mol

Measured properties

Appearance: 1,1,1-trichloroethane appears as a colorless liquid with a sweet, pleasant odor. May irritate skin, eyes and mucous membranes. In high concentrations the vapors may have a narcotic effect. Nonflammable, but may decompose and emit toxic chloride fumes if exposed to high temperatures. Used as a solvent. · Liquid
Odour: ... Mild chloroform-like odor · Sweetish
Boiling point: 165.4 °F at 760 mmHg (NTP, 1992) · 74.0 °C
Melting point: -26.5 °F (NTP, 1992) · -30 °C
Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) · In water, 1,290 mg/L at 25 °C
Density: 1.31 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.3376 at 20 °C/4 °C
Colour: colourless
Melting/freezing point: -30.4 ℃
Initial boiling point and range: 74 ℃
Flammability (solid, gas): not flammable
Upper/lower flammability or explosive limits: 8 / 16 %
Vapour pressure: 13.3 ㎪(20℃)
Water solubility: 1250 ㎎/ℓ(25℃)
Vapour density: 4.63
Relative density: 1.3376 (20℃)
n-Octanol/water partition coefficient (Kow): 2.49 (at 20℃, pH 7)
Auto-ignition temperature: 537 ℃
Decomposition temperature: 4700 ℃(Btu/lb)
Viscosity: 860 P(g/㎝·s)(20℃)
Molecular weight: 133.404

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent2
Intermediate1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as highly irritating2Classed as moderate2Classed as low2

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Severe Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: OECD 431 In Vitro Skin Corrosion: Human Skin Model Test equivalent or similar to
Skin corrosion/irritation - Category 2
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 2
Skin Irritation · Screening
Not classified
Skin Sensitization · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2
Eye Irritation · Screening