トリクロサン

米国FDA 物質登録 · UNII 4NM5039Y5X · 登録名 TRICLOSAN · 単一の化学物質

出典: 米国FDA 物質識別番号（UNII）

Triclosan is an aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. It has a role as an EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor, a fungicide, an antibacterial agent, a xenobiotic, an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a persistent organic pollutant and a drug allergen. It is a dichlorobenzene, a member of phenols, an aromatic ether and a member of monochlorobenzenes.

出典: PubChem

Triclosan is the substituted organic ether that conforms to the formula:

制限

韓国

許可された防腐剤

イギリス

出典: ASEAN 化粧品指令 · カナダ 禁止・制限成分リスト · 韓国食薬処 化粧品規制情報 · EU 化粧品規則 · 台湾FDA 化粧品成分 · 英国 化粧品規則

アルゼンチン · ブラジル

• Maximum concentration permitted at final product : 0.3%

ASEAN

• Field of application and/or use : a) Toothpastes Hand soaps Body soaps/Shower gels Deodorants (non-spray) Face powders and blemish concealers Nail products for cleaning the fingernails and toenails before the application of artificial nail systems Shampoos Hair Conditioners Facial Cleansers (b) Mouthwashes
• Maximum authorised concentration in the finished cosmetic product : (a) 0.3 % (b) 0.2 %

カナダ

• Conditions of Use by product type : (a) Mouthwashes (b) Other cosmetics (c) All oral products must meet the following conditions: Manufacturers must ensure that polychlorinated dibenzo‐p‐dioxin (PCD(d) and polychlorinated dibenzofuran (PCDF) impurities must not be present in quantities that exceed: (i) 0,1 ng/g 2,3,7,8‐tetrachlorodibenzo p‐dioxin and 2,3,7,8‐tetrachlorodibenzofuran. (ii)10 μg/g total other PCDD/PCDF impurities, with no individual impurity greater than 5 μg/g. Manufacturers must possess the following: (i) Raw material specifications for triclosan; (ii) Identification of the method of analysis used to determine the levels of PCDDs and PCDFs in triclosan; (iii) Finished product specifications.
• Maximum Concentration Permitted : ((a) 0.03% (b) 0.3%
• Warnings and Cautionary Statements: (to the effect of) : (a) "Avoid swallowing." "The product is not to be used by children under the age of 12." (c) “Avoid swallowing.” “The product is not to be used by children under the age of 12.”

台湾

• 倘前述三國家地區政府管理有差異時，則採其中限量規定方式最安全者。
• ※ 本表所稱之口腔製劑，包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
• 用途 : 防腐
• 最大配合量 : (a) 牙膏、洗手液、香皂/沐浴乳、制臭劑(噴霧劑型除外)、粉餅、粉底或使用人造指甲前之清潔指甲與趾甲用之指甲產品 : 0.3%
• (b) 漱口水產品 : 0.2%

日本

• 100gあたりの最大配合量(Maximum amount of ingredient per 100 g) : 0.10 g(0.10 g)

中国

• 最大配合量 : 0.3%

欧州連合

• Product Type, body parts : (a) Toothpastes, hand soaps, Body soaps/Shower gels, Deodorants (non-spray), Face powders and blemish concealers. Nail products for cleaning the fingernails and toenails before the application of artificial nail systems. (b) Mouthwashes
• Maximum concentration in ready for use preparation : (a) 0.3% (b) 0,2%

韓国の有害物質GHS分類: 警告 · H410 (区分1) · H315 (区分2) · H400 (区分1)

出典: 韓国 有害物質GHS情報（環境公団）

EU化粧品規則 附属書V（許可防腐剤） 第25項 · 最大濃度 0.3% · 適用 Toothpastes; Hand soaps; Body soaps/Shower gels; Deodorants (non-spray); Face powders and blemish concealers; Nail products for cleaning the fingernails and toenails before the application of artificial nail systems;

出典: EU 許可防腐剤（附属書V）

Restriction V/25 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Oinion on Triclosan Addenum to the SCCP opinion on Triclosan; Opinion concerning Triclosan; Opinion on Triclosan; Opinion on Triclosan Anti-microbial Resistance

出典: EU CosIng 成分リスト

Reviewed by CIR: Final Report: Safety Assessment of Triclosan as a Used in Cosmetics

出典: 米国CIR 安全性評価