Trifluoroacetic acid is a monocarboxylic acid that is the trifluoro derivative of acetic acid.
Definition
Trifluoroacetic acid is a monocarboxylic acid that is the trifluoro derivative of acetic acid. It has a role as a reagent and a human xenobiotic metabolite. It is functionally related to an acetic acid. It is a conjugate acid of a trifluoroacetate.
Source: PubChem
US FDA substance register · UNII E5R8Z4G708 · registered name Trifluoroacetic acid · single chemical substance
Trifluoroacetic Acid is the organic acid that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 76-05-1
- EC No.EU chemical inventory number
- 200-929-3
- DTXSIDUS EPA chemical ID
- DTXSID9041578
- DTXCIDUS EPA compound ID
- DTXCID7021578
- IUPAC
- Trifluoroacetic acid
- Molecular formula
- C2HF3O2
- Molecular weight
- 114.023 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- -15.4 ℃
- Initial boiling point and range
- 72.4 ℃
- Vapour pressure
- 110 ㎜Hg (at 25C, est.)
- Water solubility
- 1000000 ㎎/ℓ (at 20C)
- Vapour density
- 4.0
- Relative density
- 1.531
- n-Octanol/water partition coefficient (Kow)
- 0.5 (est.)
- Molecular weight
- 114.02
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Intermediate2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Category 8.2A (Category 1A)
Skin Irritation · Read Across - Classification not possible
Skin Sensitization · Screening - Category 1
Skin Irritation · Screening - Skin Corr. 1A
Skin Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Occupational airborne contact dermatitis caused by trifluoroacetic acid in an organic chemistry laboratory · 2014
- A smart methodology to fabricate electrospun chitosan nanofiber matrices for regenerative engineering applications · 2014
- Use of trifluoroacetic acid or a physiologically acceptable salt thereof as a keratolytic agent for the treatment of hyperkeratotic skin lesions · 2014
- Chemical burns caused by trifluoroacetic acid · 2013
- Double-stranded helical twisted beta-sheet channels in crystals of gramicidin S grown in the presence of trifluoroacetic and hydrochloric acids. · 2007
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese