Definition
US FDA substance register · UNII MV7XKZ9FYQ · registered name 2,4,6-Trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane · single chemical substance
Trifluoropropyl Cyclotrisiloxane is the silxane that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Korea’s toxic-substance GHS classification: Danger · H372 (category 2) · H372 (category 1) · H361 (category 2) · +1 more
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 2374-14-3
- DTXSIDUS EPA chemical ID
- DTXSID7051892
- DTXCIDUS EPA compound ID
- DTXCID5030454
- IUPAC
- 2,4,6-Trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane
- Molecular formula
- C12H21F9O3Si3
- Molecular weight
- 468.538 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 35 ℃(tran-isomer 99.5%, -1.9°C(cis-isomer 96%))
- Initial boiling point and range
- 190 ℃(1013hPa)
- Flash point
- 124 ℃(100.6kPa)
- Vapour pressure
- 88 ㎩(25°C)
- Water solubility
- 0.0000013 ㎎/ℓ(20°C)
- Relative density
- 1.2 (20°C)
- n-Octanol/water partition coefficient (Kow)
- 9 (20°C)
- Auto-ignition temperature
- 380 ℃
- Viscosity
- 3.3 cSt(20°C)
- Molecular weight
- 468.536
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Intermediate2
- Wetting agent (non-aqueous)1
- Defoamer1
- Anti-adhesive/cohesive1
- Flow promoter1
- Flame retardant1
- Monomers1
- Plasticizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to
Source: US EPA CompTox dashboard
Linked databases 12
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English