Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Definition
Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as a geroprotector, a metabolite, a biological pigment, an antineoplastic agent, a GABA modulator, an EC 1.14.18.1 (tyrosinase) inhibitor and a NMDA receptor antagonist. It is a member of chalcones and a member of (E)-2'-hydroxy-chalcones. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).
Source: PubChem
US FDA substance register · UNII B9CTI9GB8F · registered name TRIHYDROXYCHALCONE · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name トリヒドロキシカルコン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 961-29-5
- DTXSIDUS EPA chemical ID
- DTXSID2022466
- DTXCIDUS EPA compound ID
- DTXCID202466
- IUPAC
- (2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
- Molecular formula
- C15H12O4
- Molecular weight
- 256.257 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Natural Compound 2,2′,4′-Trihydroxychalcone Suppresses T Helper 17 Cell Differentiation and Disease Progression by Inhibiting Retinoid-Related Orphan Receptor Gamma T · 2022
- Antimicrobial Activity of Flavonoids From Piper lanceaefolium and Other Colombian Medicinal Plants Against Antibiotic Susceptible and Resistant Strains of Neisseria gonorrhoeae · 2011
- Isoliquiritigenin (ISL) regulates the expression of adhesion molecules, MMPs and TIMPs in DU145 human prostate cancer cells · 2007
- Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. · 2003
Linked databases 13
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- PubChem
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese