Triisopropanolamine is an amino alcohol.
- Korean limit
- 2.5%
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 6 after it (usually 1% or less).
Products using this ingredient
6 of 6 confirmed · likeliest to carry enough first
Definition
Triisopropanolamine is an amino alcohol.
Source: PubChem
US FDA substance register · UNII W9EN9DLM98 · registered name TRIISOPROPANOLAMINE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Field of application and/or use : (a) Products without rinse. (b) Other products.
- Maximum concentration permitted at final product : (a) 2.5%
- Other limitations and requirements : a.- b.- . No use with nitrosating systems . -Pureza minimum 99% maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor. 50 ug / kg -Envasar / keep in containers free of nitrites
ASEAN
- Field of application and/or use : (a) non-rinse-off products (b) other products
- Maximum authorised concentration in the finished cosmetic product : (a) 2.5%
- Other limitations and requirements : (a) (b): • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers
European Union
- Product Type, body parts : (a) Leave-on products (b) Rinse-off products
- Maximum concentration in ready for use preparation : (a) 2.5%
- Other : (a) (b) - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction III/62 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
Reviewed by CIR: Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ＴＩＰＡ: 本品は、次の化学式で表されるアルカノールアミンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 122-20-3
- EC No.EU chemical inventory number
- 204-528-4
- DTXSIDUS EPA chemical ID
- DTXSID5021415
- DTXCIDUS EPA compound ID
- DTXCID201415
- IUPAC
- 1,1',1''-Nitrilotri(propan-2-ol)
- Molecular formula
- C9H21NO3
- Molecular weight
- 191.271 g/mol
Measured properties
- Appearance
- Triisopropanolamine is a white solid with slight odor of ammonia. Denser than water. · Dry Powder, Large Crystals, Liquid, CBI, Other Solid
- Boiling point
- 581 °F at 760 mmHg (NTP, 1992) · 306 °C
- Melting point
- 113 °F (NTP, 1992) · 45 °C
- Solubility
- Soluble (NTP, 1992) · Soluble in ethanol, slightly soluble in chloroform
- Density
- 1.02 at 68 °F (USCG, 1999) - Denser than water, will sink · 1.0 at 20 °C/4 °C
- Viscosity
- 100 cps at 60 °C
- pH
- pH = 10.83
- Dissociation constant
- pKa = 8.06 /tertiary amine/
- Melting/freezing point
- 44 ℃
- Initial boiling point and range
- 300~305 ℃
- Flash point
- 160 ℃(o.c.)
- Vapour pressure
- 0.0000186 ㎜Hg (25℃ (est.))
- Water solubility
- 83 g/100㎖ (20℃)
- Relative density
- 0.988-1.02
- n-Octanol/water partition coefficient (Kow)
- -1.22
- Auto-ignition temperature
- 320 ℃
- Molecular weight
- 191.27
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 18 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- pH regulating agent4
- Processing aids not otherwise specified3
- Stabilizing agent3
- Anti-adhesive/cohesive1
- Intermediate1
- Corrosion inhibitor1
- Antioxidant1
- Catalyst1
3 other uses
- Solvent1
- UV stabilizer1
- Emulsifier1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 6 eye studies are on record.
The studies disagree (the most common conclusion covers 17%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 13 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) adopted May 12, 1981 according to - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Category 2
Skin Irritation · Screening - Not classified
Skin Sensitization · Screening - Not likely to be sensitizing
skin sensitisation · Screening · equivalent or similar to EPA OPP 81-6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 2A
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Eye Irrit. 2
Eye Irritation · Authoritative - Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) adopted May 12, 1981 according to - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Coated Microneedle System for Delivery of Clotrimazole in Deep-Skin Mycoses · 2024
- Preliminary evaluation of interactions between selected alcoholamines and model skin sebum components. · 2006
- 3: Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine · 1987
- SOBISMINOL MASS: CLINICAL RESULTS WITH ORAL ADMINISTRATION · 1939
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English