Propanoic acid, 2-methyl-, 3-hydroxy-2,2,4-trimethylpentyl ester is a carboxylic ester.
Definition
US FDA substance register · UNII ID6ZZH846Y · registered name TRIMETHYL HYDROXYPENTYL ISOBUTYRATE · mixture
Propanoic acid, 2-methyl-, 3-hydroxy-2,2,4-trimethylpentyl ester is a carboxylic ester.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name イソ酪酸トリメチルヒドロキシペンチル: 本品は、次の化学式で表されるエステルである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 25265-77-4
- EC No.EU chemical inventory number
- 246-771-9
- DTXSIDUS EPA chemical ID
- DTXSID5027857
- DTXCIDUS EPA compound ID
- DTXCID501778475
- Molecular formula
- C8H16
Measured properties
- Appearance
- 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate is a colorless liquid with a mild characteristic odor. Floats on water. (USCG, 1999) · CBI, Dry Powder, Liquid
- Boiling point
- 471 °F at 760 mmHg (USCG, 1999) · 255-260 °C
- Melting point
- -50 °C
- Solubility
- Solubility in water, g/100ml: 2
- Density
- 0.95 at 68 °F (USCG, 1999) - Less dense than water, will float · Relative density (water = 1): 0.95
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 98 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Coalescing agent40
- Solvent14
- Plasticizer9
- Film former8
- Processing aids not otherwise specified7
- UV stabilizer5
- Surfactant (surface active agent)4
- Diluent3
5 other uses
- No specific technical function3
- Binder2
- Fragrance1
- Wetting agent (non-aqueous)1
- Intermediate1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 3 eye studies are on record.
The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- Moderate or Mild Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 2B
Eye Irritation · Screening - Moderate or Mild Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Linked databases 14
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata