What is this ingredient?

미국 FDA 물질 등록 · UNII B9EIM2D97X · 등록명 TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE · 단일 화학물질

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Ingredient Dictionary

TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE

How much products actually contain

No product states its amount yet.

Of the products containing it, 88 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

12 of 88 confirmed · likeliest to carry enough first · See all 88

Definition

US FDA substance register · UNII B9EIM2D97X · registered name TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Trimethylbenzoyl Diphenylphosphine Oxide is the organic compound

Cosmetic roles

Builds artificial nailsNAIL SCULPTING

Safety & regulatory references

Banned: United Kingdom
Restricted: United Kingdom

Source: EU Cosmetics Regulation · UK cosmetics regulations (OPSS) · ASEAN Cosmetic Directive · MFDS (Korea) cosmetic regulatory information

ASEAN

Field of application and/or use : Artificial nail systems
Maximum authorised concentration in the finished cosmetic product : 5.0%
Other limitations and requirements : • Professional use
Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully

European Union

Product Type, body parts : Artificial nail systems
Maximum concentration in ready for use preparation : 5,0 %
Other : Professional use
Wording of conditions of use and warnings : For professional use only Avoid skin contact Read directions for use carefully

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1731

Source: EU prohibited substances (Annex II)

Restriction II/1731 · SCCS opinion: Opinion on Trimethylbenzoyl diphenylphosphine oxide (TPO)

Source: EU CosIng ingredient list

CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Safety Assessment of Bis Trimethylbenzoyl PhenylphosphineOxide, Ethyl Trimethylbenzoyl Phenylphosphinate, andTrimethylbenzoyl Diphenylphosphine Oxide (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name トリメチルベンゾイルジフェニルホスフィンオキシド: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDEINCI트라이메틸벤조일다이페닐포스핀옥사이드Korean label name (MFDS standard)Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-SynonymトリメチルベンゾイルジフェニルホスフィンオキシドJapanese labelling name

CAS No.chemical registry number: 75980-60-8
EC No.EU chemical inventory number: 278-355-8
DTXSIDUS EPA chemical ID: DTXSID4052502
DTXCIDUS EPA compound ID: DTXCID8031075

IUPAC: Diphenyl(2,4,6-trimethylbenzoyl)-lambda~5~-phosphanone
Molecular formula: C22H21O2P
Molecular weight: 348.382 g/mol

Measured properties

Appearance: Large Crystals, Liquid, CBI, Dry Powder · Solid (yellow powder)
Boiling point: Greater than 300 degrees C
Melting point: 93 degrees C (OECD Guideline 102)
Solubility: Water solubility: 3.3 mg/L at 20 °C (OECD Guideline 105, Flask method) and 11.9 mg/L at 20 °C (OECD Guideline 105, Column elution). Readily soluble in dichloromethane, acetone, n-butylacetate, soluble in styrene and in other monomers.
Density: 1.218 g/cm³ at 20 degrees C (OECD 109)
Stability: At least two years (cool and dry, light sensitive, to be stored in the dark)
pH: 4 to 5

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 25 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Photosensitizers14
Photosensitive agent2
Processing aids not otherwise specified2
Pigment2
Hardener1
Catalyst1
Polymerization promoter1
Softener and conditioner1

1 other uses

Monomers1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as highly irritating1Classed as low1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Federal Register 38, No 187, s1500 .41, p27029, 27 Sept 1973 according to
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) adopted July 22nd, 2010 according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) adopted May 30th, 2008
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Federal Register 38, No 187, s1500.42, p27019, 27 Sept 1973 according to