Trimethylpyrazine is a member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups.
Definition
US FDA substance register · UNII Q8PR0W8TIT · registered name 2,3,5-TRIMETHYLPYRAZINE · single chemical substance
Trimethylpyrazine is a member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups. It has a role as a pheromone, a flavouring agent, an animal metabolite, a plant metabolite and a bacterial metabolite.
Source: PubChem
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 14667-55-1
- EC No.EU chemical inventory number
- 238-712-0
- DTXSIDUS EPA chemical ID
- DTXSID1047075
- DTXCIDUS EPA compound ID
- DTXCID9027075
- IUPAC
- 2,3,5-Trimethylpyrazine
- Molecular formula
- C7H10N2
- Molecular weight
- 122.171 g/mol
Measured properties
- Appearance
- Liquid · colourless to slightly yellow liquid with a roasted nut, baked potato odour
- Boiling point
- 171 °C
- Solubility
- soluble in water, oils, organic solvents · miscible at room temperature (in ethanol)
- Density
- 0.960-0.990
- Initial boiling point and range
- 171.5 ℃
- Flash point
- 54 ℃
- Vapour pressure
- 0.608 ㎜Hg (25 ℃)
- Water solubility
- 15200 ㎎/ℓ (at 25°C)
- n-Octanol/water partition coefficient (Kow)
- 0.95
- Molecular weight
- 122.19
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance3
- Flavouring and nutrient2
Source: US EPA CompTox dashboard
Related literature
- Sedative effects of roasted green tea aroma on autonomic nervous activity, central nervous activity, and subjective mood state in healthy adults · 2025
- Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species · 2017
- Combination treatment of ligustrazine piperazine derivate DLJ14 and adriamycin inhibits progression of resistant breast cancer through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis. · 2014
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese