What is this ingredient?

미국 FDA 물질 등록 · UNII 18L31PSR28 · 등록명 TRIMYRISTIN · 단일 화학물질

Ingredient Dictionary

TRIMYRISTIN

Trimyristin is a triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by myristic (tetradecanoic) acid.

Definition

US FDA substance register · UNII 18L31PSR28 · registered name TRIMYRISTIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Trimyristin is a triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by myristic (tetradecanoic) acid. It is a triglyceride and a tetradecanoate ester.

Source: PubChem

Glycerol trimyristate

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGAdjusts thicknessVISCOSITY CONTROLLING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Amended Safety Assessment of Triglycerides as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Trilaurin, Triarachidin, Tribehenin, Tricaprin, Tricaprylin, Trierucin, Triheptanoin, Triheptylundecanoin, Triisononanoin, Triisopalmitin, Triisostearin, Trilinolein, Trimyristin, Trioctanoin, Triolein, Tripalmitin, Tripalmitolein, Triricinolein, Tristearin, Triundecanoin, Glyceryl Triacetyl Hydroxystearate, Glyceryl Triacetyl Ricinoleate, and Glyceryl Stearate Diaceate

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name トリミリスチン: 本品は、ミリスチン酸（＊）とグリセリン（＊）のトリエステルであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

TRIMYRISTININCI트라이미리스틴Korean label name (MFDS standard)Tetradecanoic acid, 1,2,3-propanetriyl esterSynonymトリミリスチンJapanese labelling name

CAS No.chemical registry number: 555-45-3
EC No.EU chemical inventory number: 209-099-7
DTXSIDUS EPA chemical ID: DTXSID701014651
DTXCIDUS EPA compound ID: DTXCID70810991

IUPAC: Propane-1,2,3-triyl tritetradecanoate
Molecular formula: C45H86O6
Molecular weight: 723.177 g/mol

Measured properties

Melting/freezing point: 56.5 ℃
Initial boiling point and range: 311 ℃
Vapour pressure: 0.000555 ㎜Hg
Water solubility: 0.000000000000009596 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 18.04
Molecular weight: 723.18

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner3
Viscosity modifier2
Humectant1
Thickening agent1
Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 4 eye studies are on record.

Classed as low5

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) adopted in 1992 according to EU Method B.6 (Skin Sensitisation) adopted in 1996
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) adopted in 1992 according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) adopted in 1992 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: "Appraisal of the safety of chemicals in foods, drugs and cosmetics" by the Staff of the Division of Pharmacology", FDA, according to Draize (1959) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) adopted in 1992 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) adopted in 1992 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to