Trimyristin is a triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by myristic (tetradecanoic) acid.
定义
美国FDA 物质登记 · UNII 18L31PSR28 · 登记名称 TRIMYRISTIN · 单一化学物质
Trimyristin is a triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by myristic (tetradecanoic) acid. It is a triglyceride and a tetradecanoate ester.
来源: PubChem
Glycerol trimyristate
化妆品中的作用
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Amended Safety Assessment of Triglycerides as Used in Cosmetics
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Report on the Safety Assessment of Trilaurin, Triarachidin, Tribehenin, Tricaprin, Tricaprylin, Trierucin, Triheptanoin, Triheptylundecanoin, Triisononanoin, Triisopalmitin, Triisostearin, Trilinolein, Trimyristin, Trioctanoin, Triolein, Tripalmitin, Tripalmitolein, Triricinolein, Tristearin, Triundecanoin, Glyceryl Triacetyl Hydroxystearate, Glyceryl Triacetyl Ricinoleate, and Glyceryl Stearate Diaceate
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 トリミリスチン: 本品は、ミリスチン酸(*)とグリセリン(*)のトリエステルであり、次の化学式で表される。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 555-45-3
- EC No.欧盟化学品目录编号
- 209-099-7
- DTXSID美国EPA化学品编号
- DTXSID701014651
- DTXCID美国EPA化合物编号
- DTXCID70810991
- IUPAC
- Propane-1,2,3-triyl tritetradecanoate
- 分子式
- C45H86O6
- 分子量
- 723.177 g/mol
实测物性
- 熔点/凝固点
- 56.5 ℃
- 初沸点和沸程
- 311 ℃
- 蒸气压
- 0.000555 ㎜Hg
- 溶解度
- 0.000000000000009596 ㎎/ℓ
- 正辛醇/水分配系数(Kow)
- 18.04
- 分子量
- 723.18
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 8 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Softener and conditioner3
- Viscosity modifier2
- Humectant1
- Thickening agent1
- Solvent1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 5 项、眼部试验 4 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 9 项试验
- Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) adopted in 1992 according to EU Method B.6 (Skin Sensitisation) adopted in 1996 - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) adopted in 1992 according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) adopted in 1992 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: "Appraisal of the safety of chemicals in foods, drugs and cosmetics" by the Staff of the Division of Pharmacology", FDA, according to Draize (1959) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) adopted in 1992 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) adopted in 1992 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
来源: 美国EPA CompTox
相关文献
- Development of SLN and NLC Enriched Hydrogels for Transdermal Delivery of Nitrendipine: In Vitro and In Vivo Characteristics · 2009
- ISOLASI JENIS ASAM LEMAK DARI BERBAGAI BAHAN BAKU : ARTIKEL REVIEW · 2023
- Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics. · 2009
- Final Report on the Safety Assessment of Trilaurin, Triarachidin, Tribehenin, Tricaprin, Tricaprylin, Trierucin, Triheptanoin, Triheptylundecanoin, Triisononanoin, Triisopalmitin, Triisostearin, Trilinolein, Trimyristin, Trioctanoin, Triolein, Tripalmitin, Tripalmitolein, Triricinolein, Tristearin, · 2001
- [Restorative effects of a saturated triglyceride of animal origin on radiodermatitis and dystrophic ulcers]. · 1961