Triphenylphosphine is a member of the class of tertiary phosphines that is phosphane in which the three hydrogens are replaced by phenyl groups.
Definition
Triphenylphosphine is a member of the class of tertiary phosphines that is phosphane in which the three hydrogens are replaced by phenyl groups. It has a role as a reducing agent. It is a member of benzenes and a tertiary phosphine.
Source: PubChem
US FDA substance register · UNII 26D26OA393 · registered name Triphenylphosphine · single chemical substance
Triphenylphosphine is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Korea’s toxic-substance GHS classification: Danger · H302 (category 4) · H317 (category 1B) · H372 (category 1) · +1 more
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name トリフェニルホスフィン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 603-35-0
- EC No.EU chemical inventory number
- 210-036-0
- DTXSIDUS EPA chemical ID
- DTXSID5026251
- DTXCIDUS EPA compound ID
- DTXCID906251
- IUPAC
- Triphenylphosphane
- Molecular formula
- C18H15P
- Molecular weight
- 262.292 g/mol
Measured properties
- Appearance
- Triphenyl phosphine appears as white crystals. (NTP, 1992) · Liquid, Dry Powder, CBI, Large Crystals, Other Solid
- Odour
- ODORLESS · odourless
- Boiling point
- greater than 680 °F at 760 mmHg (NTP, 1992) · MORE THAN 360 °C
- Melting point
- 176 °F (NTP, 1992) · 80.5 °C
- Solubility
- Insoluble (NTP, 1992) · FREELY SOL IN ETHER, SOL IN BENZENE, CHLOROFORM, GLACIAL ACETIC ACID, LESS SOL IN ALCOHOL, PRACTICALLY INSOL IN WATER
- Density
- 1.194 at 77 °F (NTP, 1992) - Denser than water, will sink · 1.075 @ 80 °C/4 °C
- Colour
- white
- Melting/freezing point
- 80 ℃
- Initial boiling point and range
- 377 ℃
- Flash point
- 180 ℃(o.c.)
- Vapour pressure
- 0.0000012 hPa(20℃)
- Water solubility
- 0.279 ㎎/ℓ(25℃)
- Vapour density
- 9
- Relative density
- 1.194 (20 °C)
- n-Octanol/water partition coefficient (Kow)
- 5.69
- Viscosity
- 4.62 cP(100 ℃)
- Molecular weight
- 262.28
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 15 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Catalyst3
- Processing aids not otherwise specified3
- Dye2
- Intermediate1
- Heat stabilizer1
- Softener and conditioner1
- Stabilizing agent1
- Hardener1
2 other uses
- UV stabilizer1
- Binder1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Sh
Skin Sensitization · Authoritative - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Category 1
Skin Sensitization · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 2
Skin Irritation · Screening - Category 2
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- EVALUATION IN VITRO OF THE GOLD(I) COMPLEX WITH TRIPHENYLPHOSPHINE AND 4-DIMETHYLAAMINEPYRIDINE AS LIGANDS IN SKIN CANCER · 2024
- Fabrication of Multitargeting and pH-Regulated Nanocomposites for Antitumor Photodynamic Therapy Based on Triphenylphosphine and Graphene Oxide. · 2019
- Investigation of Column Temperature and Validation of an HPLC-PDA Method for Hydrogen Peroxide Analysis in Hair Cosmetics under Tropical Environments · 2026
- The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner · 2025
- Triphenylphosphine · 2024
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese