Definition
US FDA substance register · UNII OU2JEB22IE · registered name TRIS(N-HYDROXYETHYL) HEXAHYDROTRIAZINE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 4719-04-4
- EC No.EU chemical inventory number
- 225-208-0
- DTXSIDUS EPA chemical ID
- DTXSID7025394
- DTXCIDUS EPA compound ID
- DTXCID405394
- IUPAC
- 2,2',2''-(1,3,5-Triazinane-1,3,5-triyl)tri(ethan-1-ol)
- Molecular formula
- C9H21N3O3
- Molecular weight
- 219.285 g/mol
Measured properties
- Vapour pressure
- 4.13E-09 ㎜Hg (25℃ (est.))
- Water solubility
- 0.3 g/100㎖
- n-Octanol/water partition coefficient (Kow)
- -4.67 (est.)
- Molecular weight
- 219.28
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative6
- Processing aids not otherwise specified3
- Biocide2
- No specific technical function2
- Deodorizer2
- Lubricating agent1
- Fuel1
- Cleaning agent1
4 other uses
- Softener and conditioner1
- Intermediate1
- Humectant1
- pH regulating agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
11 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 14 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Skin Sens. 1
Skin Sensitization · Authoritative - Sh
Skin Sensitization · Authoritative - Category 1
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Classification not possible
Skin Irritation · Screening - Skin sensitisation - category 1
Skin Sensitization · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: G. Klecak: Identification of Contact Allergens (Predictive Tests in Animals) in: Advances in Modern Toxicology Vol. 4, - Dermatotoxicology and Pharmacology - ed. F. N. Marzulli, H. I. Maibach - Pages 321 - 324 1977 - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OPPTS 870.2600 (Skin Sensitisation) - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 2A
Eye Irritation · Screening - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to
Source: US EPA CompTox dashboard
Linked databases 11
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata