Ingredient Dictionary

TRISODIUM NTA

Sodium nitrilotriacetate is an organic sodium salt composed of sodium and nitrilotriacetate ions in a 3:1 ratio.

How much products actually contain

No product states its amount yet.

Of the products containing it, 0 list it before the 1% line and 3 after it (usually 1% or less).

Products using this ingredient

3 of 3 confirmed · likeliest to carry enough first

Definition

Sodium nitrilotriacetate is an organic sodium salt composed of sodium and nitrilotriacetate ions in a 3:1 ratio. It has a role as a carcinogenic agent and a nephrotoxic agent. It contains a nitrilotriacetate(3-).

Source: PubChem

US FDA substance register · UNII E3C8R2M0XD · registered name TRISODIUM NITRILOTRIACETATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Trisodium NTA is the trisodium salt of nitrilotriacetic acid. It conforms to the formula:

Cosmetic roles

Binds metal ions to prevent spoilageCHELATING

Safety & regulatory references

Banned: ASEAN · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1490

Source: EU prohibited substances (Annex II)

Restriction II/1490 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on the new classification of substances as carcinogenic, mutagenic or toxic to reproduction according to the Commission Regulation 790/2009; Opinion on Trisodium nitrilotriacetate

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ニトリロ三酢酸３Ｎａ: 本品は、次の化学式で表されるニトリロ三酢酸の塩である。

Source: JCIA labelling names (Japan)

Names & identifiers

TRISODIUM NTAINCI트라이소듐엔티에이Korean label name (MFDS standard)Glycine, N,N-bis(carboxymethyl)-, trisodium saltSynonymニトリロ三酢酸３ＮａJapanese labelling name

CAS No.chemical registry number: 10042-84-9
CAS No.chemical registry number: 18662-53-8
CAS No.chemical registry number: 5064-31-3
EC No.EU chemical inventory number: 225-768-6
DTXSIDUS EPA chemical ID: DTXSID8027587
DTXCIDUS EPA compound ID: DTXCID907587

IUPAC: Trisodium 2,2',2''-nitrilotriacetate
Molecular formula: C6H6NNa3O6
Molecular weight: 257.084 g/mol

Measured properties

Odour: odourless
pH: (10.6~11)
Vapour pressure: 8.08E-10 ㎜Hg (25℃ (est.))
Water solubility: 100 g/100㎖ (25℃ (est.))
Relative density: 1.78
n-Octanol/water partition coefficient (Kow): -10.08 (est.)
Auto-ignition temperature: 571 ℃
Decomposition temperature: 340 ℃
Molecular weight: 257.09

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 281 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Chelating agent257
No specific technical function8
Processing aids not otherwise specified3
Corrosion inhibitor3
Softener and conditioner2
Anti-scaling agent2
Ion exchange agent2
Cleaning agent1

3 other uses

Surface modifier1
Binder1
Intermediate1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 7 eye studies are on record.

Classed as low5

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 13 studies

Category 8.2C (Category 1C)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not classified
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: OECD 406 according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Category 8.3A (Category 1)
Eye Irritation · Read Across
Category 2
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening
Eye irritation - category 2A
Eye Irritation · Screening