Definition
US FDA substance register · UNII 383V75M34E · registered name TROMETHAMINE HYDROCHLORIDE · single chemical substance
Tromethamine HCl is the amine salt that conforms to the formula:
Cosmetic roles
Inhibits microbial growthANTIMICROBIAL
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
TROMETHAMINE HCLINCI1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideSynonym
- CAS No.chemical registry number
- 1185-53-1
- EC No.EU chemical inventory number
- 214-684-5
- DTXSIDUS EPA chemical ID
- DTXSID4044373
- DTXCIDUS EPA compound ID
- DTXCID2024373
- IUPAC
- 2-Amino-2-(hydroxymethyl)propane-1,3-diol--hydrogen chloride (1/1)
- Molecular formula
- C4H12ClNO3
- Molecular weight
- 157.59 g/mol
Measured properties
- Appearance
- Dry Powder, Liquid, Other Solid · Hygroscopic solid, [Sigma-Aldrich MSDS]
- Colour
- white
- Odour
- odourless
- Initial boiling point and range
- 225~295 ℃
- Decomposition temperature
- ≥ 225 ℃
- Molecular weight
- 157.6
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
Classed as low1
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Source: US EPA CompTox dashboard
Linked databases 12
- Australian Industrial Chemicals Inventory (AICIS)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata