Ingredient Dictionary

TROMETHAMINE

Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group.

How much products actually contain

No product states its amount yet.

Of the products containing it, 1,096 list it before the 1% line and 1,217 after it (usually 1% or less).

Products using this ingredient

12 of 2,307 confirmed · likeliest to carry enough first · See all 2,307

Definition

Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 79; pKa = 8.3 at 20 C; pKa = 7.82 at 37 C. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris.

Source: PubChem

US FDA substance register · UNII 023C2WHX2V · registered name TROMETHAMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Restricted or banned: China · South Korea

Source: MFDS (Korea) cosmetic regulatory information

Argentina · Brazil

Maximum concentration permitted at final product : Under maximum secondary amine: 0.5%
Other limitations and requirements : No use with nitrosating systems. Minimum 99% -Pureza. Maximum -Tenor of secondary amines in raw materials 0.5%. Maximum nitrosamine -Tenor: 50 ug / kg. -Envasar / Nitrite - free store in containers.

ASEAN

Maximum authorised concentration in the finished cosmetic product : Maximum secondary amine content: 0.5%
Other limitations and requirements : • Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content: 0.5% (applies to raw materials) • Maximum nitrosamine content: 50 μg/kg • Keep in nitrite-free containers

European Union

Maximum concentration in ready for use preparation : Maximum secondary amine content: 0.5%
Other : - Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Restriction III/61

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Tromethamine, Aminomethyl Propanediol and Aminoethyl Propanediol as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name トロメタミン: 本品は、次の化学式で表される脂肪族アミンである。

Source: JCIA labelling names (Japan)

Names & identifiers

TROMETHAMINEINCI트로메타민Korean label name (MFDS standard)1,3-Propanediol, 2-amino-2-(hydroxymethyl)-SynonymトロメタミンJapanese labelling name

CAS No.chemical registry number: 77-86-1
EC No.EU chemical inventory number: 201-064-4
DTXSIDUS EPA chemical ID: DTXSID2023723
DTXCIDUS EPA compound ID: DTXCID503723

IUPAC: 2-Amino-2-(hydroxymethyl)propane-1,3-diol
Molecular formula: C4H11NO3
Molecular weight: 121.136 g/mol

Measured properties

Appearance: Liquid, Large Crystals, Dry Powder, Other Solid · Solid, [Merck Index] White hygroscopic crystals, [Alfa Aesar MSDS]
Odour: SLIGHT, CHARACTERISTIC ODOR
Boiling point: 219-220 °C at 10 mm Hg
Melting point: 171-172 °C
Solubility: 79.1 mg/mL in ethylene glycol, 26 mg/mL in methanol, 14.6 mg/mL in anhyd ethanol, 22 mg/mL in 95% ethanol, 14 mg/mL in dimethyl formamide, 20 mg/mL in acetone, 0.5 mg/mL in ethyl acetate, 0.4 mg/mL in olive oil, 0.1 mg/mL in cyclohexane, 0.05 mg/mL in chloroform, less than 0.05 mg/mL in carbon tetrachloride · In water, 5.50X10+5 mg/L at 25 °C
Stability: Stable in light and air
pH: pH of 0.1 molar aq soln = 10.4 · 10.4
Dissociation constant: 8.08 · pKa = 8.07
Colour: white
Melting/freezing point: 171~172 ℃
Initial boiling point and range: 219~220 ℃ (at 10mmHg)
Flash point: 170 ℃
Flammability (solid, gas): flammable
Vapour pressure: 0.000002 ㎜Hg (@ 25 ℃, est.)
Water solubility: 550000 ㎎/ℓ (@ 25 ℃)
Vapour density: 4.18
Relative density: 1.32 (@ 20.4 ℃)
n-Octanol/water partition coefficient (Kow): -1.56 (est.)
Molecular weight: 121.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 11 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

pH regulating agent5
Fragrance2
Deodorizer2
Processing aids not otherwise specified1
Intermediate1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to
Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to