Uracil is a common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4.
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 3 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
Uracil is a common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription. It has a role as a prodrug, an allergen, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and a Daphnia magna metabolite. It is a pyrimidine nucleobase and a pyrimidone. It is a tautomer of a (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one.
Source: PubChem
US FDA substance register · UNII 56HH86ZVCT · registered name Uracil · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ウラシル: 本品は、次の化学式で表される複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 66-22-8
- EC No.EU chemical inventory number
- 200-621-9
- DTXSIDUS EPA chemical ID
- DTXSID4021424
- DTXCIDUS EPA compound ID
- DTXCID101424
- IUPAC
- Pyrimidine-2,4(1H,3H)-dione
- Molecular formula
- C4H4N2O2
- Molecular weight
- 112.088 g/mol
Measured properties
- Appearance
- Solid, [Merck Index] White powder, [Alfa Aesar MSDS] · Solid
- Melting point
- 338 °C · 330 °C
- Solubility
- 3600 mg/L (at 25 °C) · 3.6 mg/mL
- Dissociation constant
- 9.45
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Synthesis and cytotoxic evaluation of uracil C-Mannich bases · 2012
- EGFR mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung · 2007
- Crystal structure of 5-fluoro-1-(carboxymethyl)uracil, C6H5FN2O4 · 2006
- Vaccinia Virus Uracil DNA Glycosylase Has an Essential Role in DNA Synthesis That Is Independent of Its Glycosylase Activity: Catalytic Site Mutations Reduce Virulence but Not Virus Replication in Cultured Cells · 2003
- Energetics of Uracil Cation Radical and Anion Radical Ion-Molecule Reactions in the Gas Phase · 2001
Linked databases 18
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese