Ingredient Dictionary

VALPROIC ACID

Valproate (Valproic acid) can cause developmental toxicity according to an independent committee of scientific and health experts.

Definition

Valproate (Valproic acid) can cause developmental toxicity according to an independent committee of scientific and health experts.

Source: PubChem

US FDA substance register · UNII 614OI1Z5WI · registered name Valproic acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

VALPROIC ACIDINCIPentanoic acid, 2-propyl-Synonym

CAS No.chemical registry number: 99-66-1
EC No.EU chemical inventory number: 202-777-3
DTXSIDUS EPA chemical ID: DTXSID6023733
DTXCIDUS EPA compound ID: DTXCID803733

IUPAC: 2-Propylpentanoic acid
Molecular formula: C8H16O2
Molecular weight: 144.214 g/mol

Measured properties

Appearance: Valproic acid is a clear colorless liquid. (NTP, 1992) · Liquid
Odour: Characteristic odor
Boiling point: 428 °F at 760 mmHg (NTP, 1992) · 222
Solubility: less than 1 mg/mL at 72 °F (NTP, 1992) · 1.3 mg/mL
Density: 0.922 at 32 °F (NTP, 1992) - Less dense than water, will float · 0.904 g/cu cm at 25 °C
Dissociation constant: 4.8 · pKa = 4.6
Colour: colourless
Initial boiling point and range: 219.5 ℃
Flash point: 111 ℃
Water solubility: 2000 ㎎/ℓ (20℃)
Relative density: 0.904 (25 ℃ / 4℃)
n-Octanol/water partition coefficient (Kow): 2.75 (exp)
Molecular weight: 144.21

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)1
Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
Classification not possible
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Classification not possible
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across