Ingredient Dictionary

VANILLIN

Vanillin is a member of the class of benzaldehydes carrying methoxy and hydroxy substituents at positions 3 and 4 respectively.

How much products actually contain

No product states its amount yet.

Of the products containing it, 378 list it before the 1% line and 189 after it (usually 1% or less).

Products using this ingredient

12 of 566 confirmed · likeliest to carry enough first · See all 566

Definition

Vanillin is a member of the class of benzaldehydes carrying methoxy and hydroxy substituents at positions 3 and 4 respectively. It has a role as an antioxidant, a flavouring agent, an anticonvulsant, an anti-inflammatory agent and a plant metabolite. It is a member of benzaldehydes, a monomethoxybenzene and a member of phenols.

Source: PubChem

US FDA substance register · UNII CHI530446X · registered name Vanillin · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

European Union

Other : The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 346

Source: EU restricted substances (Annex III)

Restriction III/346

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name バニリン: 本品は、次の化学式で表される芳香族アルデヒドである。

Source: JCIA labelling names (Japan)

Names & identifiers

VANILLININCI바닐린Korean label name (MFDS standard)Benzaldehyde, 4-hydroxy-3-methoxy-SynonymバニリンJapanese labelling name

CAS No.chemical registry number: 121-33-5
EC No.EU chemical inventory number: 204-465-2
DTXSIDUS EPA chemical ID: DTXSID0021969
DTXCIDUS EPA compound ID: DTXCID301969

IUPAC: 4-Hydroxy-3-methoxybenzaldehyde
Molecular formula: C8H8O3
Molecular weight: 152.149 g/mol

Measured properties

Appearance: Vanillin appears as white or very slightly yellow needles. · Liquid, Other Solid, Dry Powder, CBI, Large Crystals
Odour: Sweetish smell · Pleasant aromatic vanilla odor
Boiling point: 545 °F at 760 mmHg (NTP, 1992) · 285 °C
Melting point: 178 to 181 °F (NTP, 1992) · 81-83 °C
Solubility: Slightly soluble (NTP, 1992) · In water, 1.102X10+4 mg/L at 25 °C
Density: 1.056 at 68 °F (NTP, 1992) - Denser than water, will sink · 1.056
Stability: SLOWLY OXIDIZES SOMEWHAT ON EXPOSURE TO MOIST AIR, AFFECTED BY LIGHT
pH: Solutions are acid to litmus
Dissociation constant: pKa = 7.4 at 25 °C
Melting/freezing point: 81~83 ℃
Initial boiling point and range: 285 ℃
Flash point: 153 ℃(c.c.)
Flammability (solid, gas): combustible
Vapour pressure: 1.33 hPa (@ 107 ℃)
Water solubility: 11020 ㎎/ℓ (@ 25 ℃)
Vapour density: 5.2
Relative density: 1.06 (@ 20 ℃)
n-Octanol/water partition coefficient (Kow): 1.21
Auto-ignition temperature: 400 ℃
Molecular weight: 152.15

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 452 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance432
Flavouring and nutrient8
Adhesion/cohesion promoter8
Deodorizer2
Dye1
Processing aids not otherwise specified1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 3 eye studies are on record.

Classed as low6

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 11 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: EU Method B.3 (Acute toxicity (dermal)) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) Cited as Directive 84/449/EEC, B.6
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) equivalent or similar to
Not classified
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
SkinIrr2
Skin Irritation · QSAR Predicted
Severe Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) equivalent or similar to
Category 2B
Eye Irritation · Screening
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to