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Ingredient Dictionary

ZINC PYRITHIONE

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 7 list it before the 1% line and 9 after it (usually 1% or less).

Products using this ingredient

12 of 16 confirmed · likeliest to carry enough first · See all 16

Definition

US FDA substance register · UNII R953O2RHZ5 · registered name PYRITHIONE ZINC · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Zinc Pyrithione is the aromatic zinc compound

Cosmetic roles

Softens hairHAIR CONDITIONINGStops microbes growing in the productPRESERVATIVEReduces sebum productionANTI-SEBUMActs on seborrheic flaking and dandruffANTI-SEBORRHEIC

Safety & regulatory references

Banned
European Union · United Kingdom
Restricted or banned
European Union · South Korea · Taiwan
Restricted
Taiwan
Allowed preservative
Taiwan

Source: EU Cosmetics Regulation · UK cosmetics regulations (OPSS) · MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · Japan Standards for Cosmetics

Argentina · Brazil

  • Field of application and/or use : Agente anticaspa em produtos para o cabelo que se enxáguem.
  • Maximum concentration permitted at final product : 1%

ASEAN

  • Field of application and/or use : (a) Leave-on hair products (b) Rinse-off hair products
  • Maximum authorised concentration in the finished cosmetic product : (a) 0.1 % (b) 2.0%
  • Other limitations and requirements : For purposes other than inhibiting the development of microorganisms in the product. This purpose has to be apparent from the presentation of the product As a preservative, see Annexe VI, Part 1, No 8

Japan

  • Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.10 g
  • Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.010 g
  • Maximum amount per 100 g (Cosmetics that may be used for mucosa) : 0.010 g

China

  • Maximum concentration : 1.5%/0.1%
  • Maximum concentration : 0.5%

Source: MFDS (Korea) cosmetic regulatory information

Korea’s toxic-substance GHS classification: Danger · H330 (category 2) · H301 (category 3) · H318 (category 1) · +4 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1670

Source: EU prohibited substances (Annex II)

Restriction Annex II/1670 · SCCS opinion: ADDENDUM to the scientific opinion on Zinc pyrithione (P81) ref. SCCS/1512/13; Opinion concerning Zinc Pyrithione; Opinion on Zinc pyrithione P81; OPINION ON Zinc Pyrithione (ZPT) (CAS No 13463-41-7) -Submission III

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ジンクピリチオン: 本品は、次の化学式で表される芳香族亜鉛化合物である。

Source: JCIA labelling names (Japan)

JCIA labelling name ピリチオン亜鉛: 本品は、次の化学式で表される芳香族亜鉛化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

ZINC PYRITHIONEINCI징크피리치온Korean label name (MFDS standard)Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-SynonymジンクピリチオンJapanese labelling nameピリチオン亜鉛Japanese labelling name
CAS No.chemical registry number
13463-41-7
EC No.EU chemical inventory number
236-671-3
DTXSIDUS EPA chemical ID
DTXSID7026314
DTXCIDUS EPA compound ID
DTXCID90820451
IUPAC
Bis[2-(sulfanylidene-kappaS)pyridin-1(2H)-olato-kappaO]zinc
Molecular formula
C10H8N2O2S2Zn
Molecular weight
317.69 g/mol

What products actually use it for

What the 91 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Biocide41
  • Preservative28
  • Anti-dandruff (EPA)11
  • Degradant/impurity (EPA)4
  • Softener and conditioner3
  • Processing aids not otherwise specified2
  • Pharmaceutical (EPA)2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 4 eye studies are on record.

Classed as moderate1Classed as low4

The studies disagree (the most common conclusion covers 20%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 10 studies
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to EPA OTS 798.4100 (Skin Sensitisation)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
  • Category 2
    Skin Irritation · Screening
  • Category 1
    Skin Sensitization · Screening
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to
  • Category 8.3A (Category 1)
    Eye Irritation · Read Across
  • Category 2A
    Eye Irritation · Screening
  • Corrosive or Irritation Persists for > 21 days
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 26

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