Zingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively.
Definition
Zingerone is a methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger. It has a role as an antioxidant, a flavouring agent, a fragrance, an antiemetic, a radiation protective agent, an anti-inflammatory agent and a plant metabolite. It is a monomethoxybenzene, a member of phenols and a methyl ketone.
Source: PubChem
US FDA substance register · UNII 4MMW850892 · registered name ZINGERONE · single chemical substance
Zingerone is the organic compound that conforms to the formula
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 122-48-5
- EC No.EU chemical inventory number
- 204-548-3
- DTXSIDUS EPA chemical ID
- DTXSID8047420
- DTXCIDUS EPA compound ID
- DTXCID6027420
- IUPAC
- 4-(4-Hydroxy-3-methoxyphenyl)butan-2-one
- Molecular formula
- C11H14O3
- Molecular weight
- 194.23 g/mol
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance5
- Flavouring and nutrient3
Source: US EPA CompTox dashboard
Related literature
- Zingerone Targets LKB1/AMPK to Block FcεRI-Dependent Mast Cell Degranulation and Anaphylaxis · 2025
- MXene-zingerone synergized gelatin-based hydrogel for accelerated open wound healing and epidermal regeneration in a preclinical model. · 2025
- Phytoconstituent-derived zingerone nanoparticles disrupt the cell adhesion mechanism and suppress cell motility in melanoma B16F10 cells. · 2024
- Prospective randomized double‐blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging · 2024
- Open‐label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation · 2024
Linked databases 13
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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