Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.
- Dark spots C
- Amount studies used
- 2–5%
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
9 products state the amountmedian 7%100% at or above the amount studies used (2–5%)
- under 0.01% 0
- 0.01–0.1% 0
- 0.1–1% 0
- 1% or more 9
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
3 products are filed with Korea's MFDS as brightening functional cosmetics, which fixes it at the notified amount (2–5%) or more.
Of the products containing it, 94 list it before the 1% line and 80 after it (usually 1% or less).
Where no amount is stated, a product listing it early reaches the study amount about 79% of the time, one listing it late about 5%.
Clinical evidence grade by skin concern
- C
- uncontrolled or multi-ingredient studies
Products using this ingredient
12 of 173 confirmed · likeliest to carry enough first · See all 173
TOSOWOONGArbutin 7% + Tranexamic Acid 4% Cream7% stated · study amount
TOSOWOONGArbutin 7.0 Intensive Spot Cream7% stated · study amount
TOSOWOONGArbutin 7% + Tranexamic Acid 4% Booster Shot7% stated · study amount
TOSOWOONGArbutin 7% Glutathione Cream7% stated · study amount
TOSOWOONGNiacinamide 10% + Arbutin 7% Serum7% stated · study amount
Cos De BAHAAN Serum5% stated · study amount
SidmoolNatural Whitening Moisture Cream5% stated · study amount
SidmoolSkin Source Ultra Albutin Cream3% stated · study amount
SidmoolGalatokside Whitening Cream2% stated · study amount
SOMEBLOSSOMSPICULAR EYEBAG CREAMMFDS brightening amount
isoiIntensive Lifting Serum 20mlMFDS brightening amount
RIREBlemish White StickMFDS brightening amount
Definition
Arbutin (or beta arbutin) is the organic compound that conforms to the formula:
Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a hydroquinone.
Source: PubChem
US FDA substance register · UNII C5INA23HXF · registered name ARBUTIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Taiwan
- Maximum concentration : 7%
European Union
- Product Type, body parts : Face cream
- Maximum concentration in ready for use preparation : 7 %
- Wording of conditions of use and warnings : Hydroquinone levels shall remain as low as possible in formulations containing Arbutin and shall not be higher than the unavoidable trace level.
Source: MFDS (Korea) cosmetic regulatory information
EU Cosmetics Regulation, Annex III (restricted substances), entry 378 · maximum concentration 7 % · applies to Face cream
Restriction III/378 · SCCS opinion: Opinion on beta-Arbutin
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アルブチン: 本品は、次の化学式で表される糖誘導体である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 497-76-7
- EC No.EU chemical inventory number
- 207-850-3
- DTXSIDUS EPA chemical ID
- DTXSID7040152
- DTXCIDUS EPA compound ID
- DTXCID5020152
- IUPAC
- 4-Hydroxyphenyl beta-D-glucopyranoside
- Molecular formula
- C12H16O7
- Molecular weight
- 272.253 g/mol
Measured properties
- Appearance
- Solid · Colorless elongated prisms from moist ethyl acetate
- Melting point
- 197 · 199 °C
- Solubility
- ≥ 10g/100g · Slightly soluble in ethyl ether, insoluble in benzene, chloroform, CS2
- Vapour pressure
- 0.0000000000023 (NLM)
- Water solubility
- 959000 (NLM)
- Molecular weight
- 272.251
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Antioxidant2
- Bleaching agent1
Source: US EPA CompTox dashboard
Related literature
- Chemical and Biocatalytic Routes to Arbutin · 2019
- The molecular mechanisms underlying optical isomer arbutin permeating the skin: The molecular interaction between arbutin and skin components. · 2024
- Molecular modeling and phenoloxidase inhibitory activity of arbutin and arbutin undecylenic acid ester. · 2021
- Content determination of arbutin and its intermediate · 2012
- [Determination of alpha-arbutin, beta-arbutin and niacinamide in cosmetics by high performance liquid chromatography]. · 2010
Linked databases 22
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese