3-tert-butyl-4-hydroxyanisole is an aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho- to the phenolic hydroxy group is replaced by a tert-butyl group.
How much products actually contain
No product states its amount yet.
Of the products containing it, 6 list it before the 1% line and 31 after it (usually 1% or less).
Products using this ingredient
12 of 37 confirmed · likeliest to carry enough first · See all 37
HourglassHourglass Unreal™ High Shine Volumizing Lip Gloss
Biome ActivateRetinol 0.5% Ampoule
WISELYOpenwork Cica Repair Serum
MuradMurad Prevent + Renew with Retinol Boosters
LALARECIPELALARECIPE Bakuchinol Glow Balm
MEDIPEELMEDIPEEL Retinol Collagen Lifting Toner 150ml
JM solutionSkin Boost Retinol Micellar Cleansing Water 1.5 500ml
JM solutionJM solution Skin Boost Retinol 0.1% Serum 1.0 30ml
OuidadOuidad VitalCurl®+ Clear & Gentle Shampoo
JM solutionJM solution Skin Boost Retinol Toner XL 1.0 600ml
JM solutionJM solution Skin Boost Retinol Cleansing Foam 1.5 150ml
JM solutionJM solution Retinol Lifting Toner Pad 175ml 100 Pads
Definition
3-tert-butyl-4-hydroxyanisole is an aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho- to the phenolic hydroxy group is replaced by a tert-butyl group. It has a role as an antioxidant and a human xenobiotic metabolite. It is a member of phenols and an aromatic ether.
Source: PubChem
US FDA substance register · UNII REK4960K2U · registered name BUTYLATED HYDROXYANISOLE · mixture
BHA is a mixture of isomers of tertiary butyl-substituted 4-methoxyphenols. It consists chiefly of 3-t-butyl-4-hydroxyanisole with lesser amounts of 2-t-butyl-4-hydroxyanisole. It conforms generally to the formula:
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Final Report: Safety Assessment of BHA as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name BHA: 本品は、4-メトキシフェノールに t-ブチル基が置換したものの混合物である。主に3-t-ブチル-4-ヒドロキシアニソールからなり、少量の2-t-ブチル-4-ヒドロキシアニソールを含み、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 25013-16-5
- EC No.EU chemical inventory number
- 246-563-8
- DTXSIDUS EPA chemical ID
- DTXSID7020215
- DTXCIDUS EPA compound ID
- DTXCID701285159
- Molecular formula
- C11H16O2
What products actually use it for
What the 19 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant8
- Processing aids not otherwise specified2
- Fragrance2
- Deodorizer2
- Flavouring and nutrient1
- Biocide1
- Filler1
- Food preservative (EPA)1
1 other uses
- Oxidizing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 5 studies
- Category 6.5B (Category 1)
Skin Sensitization · Read Across - SkinIrr2
Skin Irritation · QSAR Predicted - Category 1
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Tert-butylhydroquinone and tert-butylcatechol positivity as warning lights of skin sensitization to tert-butylphenol derivatives in adhesives and diabetes devices. · 2024 · Contact dermatitis
- Dermatological Safety of Cosmetic Products Marketed to Children: Insights on the Sephora Kids Phenomenon. · 2025 · Journal of drugs in dermatology : JDD
- Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment. · 2025 · Journal of cosmetic dermatology
- The clinical efficacy and tolerability of a novel triple acid exfoliating blend for reducing signs of photoaging in sensitive skin. · 2024 · Journal of cosmetic dermatology
- The key constituents underlying the combined toxicity of eight cosmetic contaminants towards Vibrio qinghaiensis. · 2023 · Environmental science. Processes & impacts
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU SCCS safety opinions
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- PubMed 2 3 4 5
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese