COLLAGEN

Collagens. A fibrous protein comprising one third of the total protein in mammalian organisms. It is a polypeptide containing three peptide chains and rich in proline and hydroxyproline

米国FDA 物質登録 · UNII 8JC99XGU4W · 登録名 MARINE COLLAGEN, SOLUBLE · 混合物

出典: 米国FDA 物質識別番号（UNII）

Collagen supplementation and topical use are typically safe and well tolerated with minimal adverse effects reported. Formulation quality affects topical collagen stability and efficacy.

Collagen is an abundant extracellular matrix protein forming the scaffold structure of skin, bones, and connective tissues. Aging causes collagen to degrade and production to decline, leading to wrinkles, sagging, and thinning skin. Collagen peptides in supplements or topical products can stimulate fibroblasts to increase collagen and elastin synthesis, restoring skin structure and resilience. Oral collagen peptides are absorbed and distributed to connective tissue, promoting tighter skin and improved hydration. Topical collagen provides surface hydration though its high molecular weight limits penetration into deeper layers. Additionally, collagen exhibits antioxidant properties reducing oxidative stress, boosts skin repair processes, and slows aging by downregulating metalloproteinases responsible for collagen breakdown. Clinical studies indicate improvements in skin elasticity, density, wrinkle reduction, hydration, and texture with collagen supplementation or topical use.

韓国の有害物質GHS分類なし · 既存化学物質

出典: 韓国 有害物質GHS情報（環境公団）

Other restriction: ban substances that deplete the ozone layer

出典: EU CosIng 成分リスト

Reviewed by CIR: Safety Assessment of Skin and Connective Tissue-Derived Proteins and Peptides as Used in Cosmetics

出典: 米国CIR 安全性評価