How much products actually contain
No product states its amount yet.
Of the products containing it, 71 list it before the 1% line and 53 after it (usually 1% or less).
Products using this ingredient
12 of 124 confirmed · likeliest to carry enough first · See all 124
VTVT Cica Reti-A Essence 0.7
K18K18 FutureIQ™ biomimetic hair longevity serum
OribeOribe Serene Scalp Densifying Treatment Spray
DermafirmPeptology Boosting Ampoule Retinoid 30ml
VTVT Cica Reti-A Essence 0.3
The OrdinaryNiacinamide 10%
philosophyphilosophy Eye Power Treatment Fill & Firm
MuradMurad Retinol Youth Renewal Eye Serum
BubbleBubble Float On
StarfaceStarface star cream® + salicylic acid
PrimeraPDRN-Niacinamide 10 Toning Glow Serum 30g (Set/Single)
The OrdinaryGranactive Retinoid 2% Emulsion 30ml
Definition
US FDA substance register · UNII SA6A6V432S · registered name DIMETHYL ISOSORBIDE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ジメチルイソソルバイド: 本品は、無水ソルビトール異性体のジメチルエーテルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5306-85-4
- EC No.EU chemical inventory number
- 226-159-8
- DTXSIDUS EPA chemical ID
- DTXSID201019399
- DTXCIDUS EPA compound ID
- DTXCID201477371
- IUPAC
- 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
- Molecular formula
- C8H14O4
- Molecular weight
- 174.196 g/mol
Measured properties
- Appearance
- Liquid
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Viscosity modifier3
- Solvent2
- Solubility enhancer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) 24 April 2002 - Ambiguous
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 24 Apr 2002 according to
Source: US EPA CompTox dashboard
Related literature
- Green fabrication of PHBV microbeads using a dimethyl isosorbide solvent for skin exfoliators · 2023
- Lignin Nanoparticles as Sustainable Photoprotective Carriers for Sunscreen Filters · 2022
- Dimethyl isosorbide, a polyol, and the phenolic or phenolic-based compositions for topical application containing an antioxidant · 2016
- Solubilizing and Hydrotropic Properties of Isosorbide Monoalkyl- and Dimethyl-Ethers · 2009
- Treatment of aphthous stomatitis with saturated potassium nitrate/dimethyl isosorbide. · 2004
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata