Ingredient Dictionary

HESPERIDIN

Hesperidin is a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

How much products actually contain

2 products state the amountmedian 0.00000001%

under 0.01% 2
0.01–0.1% 0
0.1–1% 0
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 0 list it before the 1% line and 21 after it (usually 1% or less).

Products using this ingredient

12 of 21 confirmed · likeliest to carry enough first · See all 21

Definition

Hesperidin is a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a mutagen. It is a member of 4'-methoxyflavanones, a rutinoside, a monomethoxyflavanone, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a disaccharide derivative and a flavanone glycoside. It is functionally related to a hesperetin.

Source: PubChem

US FDA substance register · UNII E750O06Y6O · registered name HESPERIDIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Makes skin soft and smoothSKIN CONDITIONING - EMOLLIENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヘスペリジン: 本品は、レモンやスイートオレンジ等に存在する主要なフラボノイドであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

HESPERIDININCI헤스페리딘Korean label name (MFDS standard)4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-SynonymヘスペリジンJapanese labelling name

CAS No.chemical registry number: 520-26-3
EC No.EU chemical inventory number: 208-288-1
DTXSIDUS EPA chemical ID: DTXSID9044328
DTXCIDUS EPA compound ID: DTXCID7024328

IUPAC: (2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
Molecular formula: C28H34O15
Molecular weight: 610.565 g/mol

Measured properties

Melting/freezing point: 258~262 ℃
n-Octanol/water partition coefficient (Kow): -0.72

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient2
Softener and conditioner1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 2 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) according to EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to