Hexane-1,6-diol is a diol that is hexane substituted by hydroxy groups at positions 1 and 6.
How much products actually contain
No product states its amount yet.
Of the products containing it, 4 list it before the 1% line and 4 after it (usually 1% or less).
Products using this ingredient
8 of 8 confirmed · likeliest to carry enough first
Ariul7 Days Mask Aloe H 10 Sheets
Nails.INCNails.INC Glazed Candy Chrome Glow Nail Glaze
DermafirmAge Reviving Micro Crystal Patch (1 Pouch: 2 Under-Eye/Nasolabial Patches + 1 Glabella Patch)
CharmzoneCharmzone ChamCell Cream
HanyulPure Artemisia Light Deep Cleansing Oil 200ml
DermalogicaDermalogica sound sleep cocoon night gel-cream
MiseenscenePerfect Hair Mask 180g
Dr.FORHAIRFolligen Bio-3 Shampoo 750ml
Definition
Hexane-1,6-diol is a diol that is hexane substituted by hydroxy groups at positions 1 and 6. It is a primary alcohol and a diol. It derives from a hydride of a hexane.
Source: PubChem
US FDA substance register · UNII ZIA319275I · registered name HEXANEDIOL · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Alkane Diols as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ヘキサンジオール: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 26762-52-7
- CAS No.chemical registry number
- 629-11-8
- EC No.EU chemical inventory number
- 211-074-0
- DTXSIDUS EPA chemical ID
- DTXSID1027265
- DTXCIDUS EPA compound ID
- DTXCID907265
- IUPAC
- Hexane-1,6-diol
- Molecular formula
- C6H14O2
- Molecular weight
- 118.176 g/mol
Measured properties
- Appearance
- Other Solid, CBI, Liquid · Colorless or white, hygroscopic solid, [CHEMINFO]
- Boiling point
- 250 °C · 208 °C
- Melting point
- 45 °C · 41.5 °C
- Solubility
- Soluble in water · Soluble in alcohol, sparingly soluble in hot ether.
- Density
- 0.967 g/cu cm at 25 °C · Density: 0.953 g/cm cu at 50 °C
- Stability
- Stable under recommended storage conditions.
- Colour
- colourless
- Melting/freezing point
- 42.8 ℃
- Initial boiling point and range
- 208 ℃
- Flash point
- 147 ℃(c.c.)
- Flammability (solid, gas)
- combustible
- Upper/lower flammability or explosive limits
- 16 / 6.6 %
- Vapour pressure
- 0.0005 ㎜Hg (at 25 ℃)
- Water solubility
- 22700 ㎎/ℓ (@ 25 ℃, est.)
- Vapour density
- 4.1
- Relative density
- 0.967 (@ 0 ℃)
- n-Octanol/water partition coefficient (Kow)
- -0.11
- Auto-ignition temperature
- 320 ℃
- Viscosity
- 61 cP (@ 43 ℃)
- Molecular weight
- 118.17
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 17 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Monomers6
- Processing aids not otherwise specified3
- Intermediate3
- Solvent3
- Elasticizer1
- Dehydrating agent (desiccant)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to other guideline: Japan MAFF Testing Guideline of 12 Nousan No. 8147 according to
Source: US EPA CompTox dashboard
Related literature
- Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol. · 2024
- Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing. · 2020
- Food‐grade antimicrobials potentiate the antibacterial activity of 1,2‐hexanediol · 2015
- Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol · 2009
- Repeated exposure toxicity of 2-ethyl-1,3-hexanediol by cutaneous applications to the rat for 9 and 90 days. · 1995
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese