Ingredient Dictionary

HISTIDINE

L-histidine is the L-enantiomer of the amino acid histidine.

How much products actually contain

12 products state the amountmedian 0.000015%

under 0.01% 12
0.01–0.1% 0
0.1–1% 0
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 140 list it before the 1% line and 548 after it (usually 1% or less).

Products using this ingredient

12 of 681 confirmed · likeliest to carry enough first · See all 681

Definition

L-histidine is the L-enantiomer of the amino acid histidine. It has a role as a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a L-alpha-amino acid, a histidine and a proteinogenic amino acid. It is a conjugate base of a L-histidinium(1+). It is a conjugate acid of a L-histidinate(1-). It is an enantiomer of a D-histidine. It is a tautomer of a L-histidine zwitterion.

Source: PubChem

US FDA substance register · UNII 4QD397987E · registered name Histidine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Draws in and holds moistureHUMECTANTReduces staticANTISTATICKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Safety Assessment of alpha-Amino Acids as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ヒスチジン: 本品は、次の化学式で表されるアミノ酸である。

Source: JCIA labelling names (Japan)

Names & identifiers

HISTIDINEINCI히스티딘Korean label name (MFDS standard)L-HistidineSynonymヒスチジンJapanese labelling name

CAS No.chemical registry number: 4998-57-6
CAS No.chemical registry number: 71-00-1
EC No.EU chemical inventory number: 200-745-3
EC No.EU chemical inventory number: 225-660-9
DTXSIDUS EPA chemical ID: DTXSID9023126
DTXCIDUS EPA compound ID: DTXCID503126

IUPAC: L-Histidine
Molecular formula: C6H9N3O2
Molecular weight: 155.157 g/mol

Measured properties

Appearance: Solid, [Merck Index] Powder, [Sigma-Aldrich MSDS] · Solid
Melting point: 287 dec °C · 287 °C (decomp)
Solubility: 45600 mg/L (at 25 °C) · Fairly sol in water, insol in alcohol and ether, decomp 251-252 °C, specific optical rotation (c= 2 in 3 moles of HCl): +8.0 deg at 26 °C/D /Monohydrochloride/
Dissociation constant: 2.76 (at 0 °C) · pK1'= 1.78, pK2'= 5.97, pK3'= 8.97
Colour: colourless
Flash point: 282 ℃
Flammability (solid, gas): flammable
Vapour pressure: 0.00000000599 ㎜Hg (@ 25 ℃, est.)
Water solubility: 45600 ㎎/ℓ (at 25 ℃)
Vapour density: 5.36
n-Octanol/water partition coefficient (Kow): -3.32
Decomposition temperature: 287 ℃
Molecular weight: 155.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 7 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient4
Humectant1
Softener and conditioner1
Anti-static agent1

Source: US EPA CompTox dashboard