- Skin barrier B+
- Dryness C
- Amount studies used
- 1–5%
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
240 products state the amountmedian 0.5%42% at or above the amount studies used (1–5%)
- under 0.01% 51
- 0.01–0.1% 28
- 0.1–1% 61
- 1% or more 100
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 3,490 list it before the 1% line and 2,200 after it (usually 1% or less).
Where no amount is stated, a product listing it early reaches the study amount about 59% of the time, one listing it late about 11%.
Clinical evidence grade by skin concern
- B
- one or two randomised trials
- C
- uncontrolled or multi-ingredient studies
Products using this ingredient
12 of 5,644 confirmed · likeliest to carry enough first · See all 5,644
TOSOWOONGPanthenol 20% Barrier Cream20% stated · study amount
SidmoolD-Panthenol 20 Multi Balm20% stated · study amount
KIOSKINKIOSKIN D-Panthenol 18.5 Cream19% stated · study amount
TOSOWOONGDexpanthenol Cream17% stated · study amount
KIOSKINKIOSKIN D-Panthenol 15.5 Barrier Repair Cream16% stated · study amount
SidmoolPanthenol Barrier Cream15% stated · study amount
ATOPALMPanthenol Cream 80ml (Single/Special Set)10% stated · study amount
ATOPALMPanthenol Lotion 180ml10% stated · study amount
AXIS-YAXIS-Y Panthenol 10 Skin Smoothing Shield Cream10% stated · study amount
COSNORICOSNORI Panthenol Barrier Ampoule10% stated · study amount
RIREEGF Dipanthen Repair Eye Cream7% stated · study amount
RIREEGF Dipanthen Repair Cream7% stated · study amount
Cosmetic roles
Safety & regulatory references
Japan
- <DL-Pantothenyl Alcohol>
Source: MFDS (Korea) cosmetic regulatory information
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
Reviewed by CIR: Final Report on the Safety Assessment of Panthenol and Pantothenic Acid
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name パンテノール: 本品は、次の化学式で表されるアミドアルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 16485-10-2
- CAS No.chemical registry number
- 81-13-0
- CAS No.chemical registry number
- 81-13-0 / 16485-10-2
- EC No.EU chemical inventory number
- 201-327-3
- EC No.EU chemical inventory number
- 240-540-6
Measured properties
- Appearance
- Solid · Hygroscopic oil
- Boiling point
- Decomposes · BP: 118-120 °C at 0.02 mm Hg, somewhat hygroscopic, easily decomposes on distillation.
- Melting point
- < 25 °C
- Solubility
- Freely soluble in methanol, water, alcohol, slightly soluble in ether · Very soluble in ethanol, methanol, slightly soluble in ethyl ether
- Density
- 1.2 at 20 °C/20 °C
- Stability
- Reasonably stable to usual sterilization time and temp in aqueous solution at pH 3.0-4.0, long heating causes racemization. · Usually more stable than salts of pantothenic acid if pH can be adjusted between 3 and 5.
- pH
- pH 9.5
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
Related literature
- De novo biosynthesis of D-panthenol in engineered E. coli with rationally designed L-homoserine decarboxylase. · 2025
- Emulsions containing allantoin and D-panthenol as attractive moisturizing agents · 2024
- How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies · 2023
- Unlocking the Potential of Fermentation in Cosmetics: A Review · 2023
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics · 2022
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL 2
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary 2
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- OpenAlex 2
- PubChem
- Tlooto literature search 2 3
- UniChem cross-reference IDs 2
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA DSSTox chemical database 2
- US FDA substance registration (GSRS) 2
- Wikidata 2