Propane-1,3-diol is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3,765 list it before the 1% line and 1,169 after it (usually 1% or less).
Products using this ingredient
12 of 4,893 confirmed · likeliest to carry enough first · See all 4,893
Lip LeafSteaming Lip Mask
FentyFenty Blemish Defeat'r BHA Spot-Targeting Gel
FentyFenty Fat Water Hydrating Milky Toner Essence with Hyaluronic Acid + Tamarind
Camille RoseCamille Rose Honey "Leave-in Collection"
FarmacyFarmacy 10% Waterless Vitamin C Serum Trial Size
FarmacyFarmacy Bright On 10% Waterless Vitamin C Serum
Biome ActivateResveratrol Ampoule
Cos De BAHAVA Serum
EZ FormulaEZ Formula Glow 2X Brightening Pure Vitamin C Ampoule
BRTCMelite C-20 Ampoule
ROUND LABBirch Moisturizing Mild-Up Sunscreen 50ml
ROUND LABCamellia Deep Collagen Firming Sun Serum 50ml
Definition
Propane-1,3-diol is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group. A colourless, viscous, water-miscible liquid with a high (210C) boiling point, it is used in the synthesis of certain polymers and as a solvent and antifreeze. It has a role as a metabolite and a protic solvent.
Source: PubChem
US FDA substance register · UNII 5965N8W85T · registered name Propanediol · single chemical substance
Propanediol is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Safety Assessment of Alkane Diols as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name プロパンジオール: 本品は、次の化学式で表される二価アルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 26264-14-2
- CAS No.chemical registry number
- 504-63-2
- EC No.EU chemical inventory number
- 207-997-3
- DTXSIDUS EPA chemical ID
- DTXSID8041246
- DTXCIDUS EPA compound ID
- DTXCID6021246
- IUPAC
- Propane-1,3-diol
- Molecular formula
- C3H8O2
- Molecular weight
- 76.095 g/mol
Measured properties
- Appearance
- Liquid, Other Solid · Colorless to pale yellow liquid, [Merck Index] Colorless odorless liquid, [Alfa Aesar MSDS]
- Boiling point
- 210-212 °C
- Solubility
- Miscible with water · Very soluble in ethyl ether, slightly soluble in benzene
- Density
- 1.0597 at 20 °C/4 °C · 1.0536 @25 °C
- Stability
- Chemical stability: Stable under recommended storage conditions.
- Melting/freezing point
- -26.7 ℃
- Initial boiling point and range
- 214 ℃
- Flash point
- &, gt, 99 ℃ (Tag Closed Cup @ 755.4 mmHg)
- Upper/lower flammability or explosive limits
- 16.6 / 2.6 %
- Vapour pressure
- 0.0441 ㎜Hg(@ 25 ℃)
- Water solubility
- 1000000 ㎎/ℓ(@ 25 ℃, est.)
- Vapour density
- 2.6
- Relative density
- 1.0597
- n-Octanol/water partition coefficient (Kow)
- -1.04
- Auto-ignition temperature
- 405 ℃
- Viscosity
- 48.45 cP(20.25℃)
- Molecular weight
- 76.0942
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 12 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent4
- Chemical reaction regulator1
- Polymerization promoter1
- Anti-freeze agent1
- Diluent1
- Elasticizer1
- Stabilizing agent1
- Fragrance1
1 other uses
- Humectant1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Dereplication of Natural Extracts Diluted in Propylene Glycol, 1,3-Propanediol and Glycerin. Comparison of Leontopodium alpinum Cass. (Edelweiss) Extracts as a Case Study · 2021
- The influence of UV irradiation on fish skin collagen films in the presence of xanthohumol and propanediol. · 2022
- Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays · 2021
- Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics · 2018
- Preparation and Property Testing of Antheraea pernyi Silk Fibroin/Propanediol Blend Films · 2011
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese